Lanthanide DO3A-Tropone Complexes: Efficient Dual MR/NIR Imaging Probes in Aqueous Medium

Zohreh Hashami; Andre F. Martins; Alexander M. Funk; Veronica Clavijo Jordan; Stéphane Petoud; Svetlana V. Eliseeva; Zoltan Kovacs

doi:10.1002/ejic.201701240

Lanthanide DO3A-Tropone Complexes: Efficient Dual MR/NIR Imaging Probes in Aqueous Medium

Zohreh Hashami, Andre F. Martins, Alexander M. Funk, Veronica Clavijo Jordan, Stéphane Petoud, Svetlana V. Eliseeva, Zoltan Kovacs

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Invited for the cover of this issue are the groups of Zoltan Kovacs from the University of Texas Southwestern Medical Center, USA, and Svetlana Eliseeva from Centre de Biophysique Moléculaire, Orléans, France. The cover image shows the structure of a DOTA-based ligand, whose lanthanide complexes are useful imaging probes.

Original language	English (US)
Pages (from-to)	4963
Number of pages	1
Journal	European Journal of Inorganic Chemistry
Volume	2017
Issue number	43
DOIs	https://doi.org/10.1002/ejic.201701240
State	Published - Nov 24 2017

ASJC Scopus subject areas

Inorganic Chemistry

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Lanthanide DO3A-Tropone Complexes : Efficient Dual MR/NIR Imaging Probes in Aqueous Medium. / Hashami, Zohreh; Martins, Andre F.; Funk, Alexander M.; Jordan, Veronica Clavijo; Petoud, Stéphane; Eliseeva, Svetlana V.; Kovacs, Zoltan.

In: European Journal of Inorganic Chemistry, Vol. 2017, No. 43, 24.11.2017, p. 4963.

Research output: Contribution to journal › Comment/debate › peer-review

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title = "Lanthanide DO3A-Tropone Complexes: Efficient Dual MR/NIR Imaging Probes in Aqueous Medium",

abstract = "Invited for the cover of this issue are the groups of Zoltan Kovacs from the University of Texas Southwestern Medical Center, USA, and Svetlana Eliseeva from Centre de Biophysique Mol{\'e}culaire, Orl{\'e}ans, France. The cover image shows the structure of a DOTA-based ligand, whose lanthanide complexes are useful imaging probes.",

author = "Zohreh Hashami and Martins, {Andre F.} and Funk, {Alexander M.} and Jordan, {Veronica Clavijo} and St{\'e}phane Petoud and Eliseeva, {Svetlana V.} and Zoltan Kovacs",

note = "Funding Information: Lanthanide-based dual imaging probes have great potential, but there are several obstacles that must be overcome before they can be translated into practical biomedical applications. High in vivo stability is necessary to minimize toxicity. We ad- dressed this problem by using a ligand system based on DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), as these chelators form kinetically inert complexes. It is also desirable to shift the excitation wavelength above 600 nm to minimize absorption and scattering by biological tissue. This could be achieved by modifying the tropone chromophore. Who pays the bill for the research highlighted on the cover? This research was partly funded by a National Institutes of Health (NIH) Biotechnology Resource Grant (National Center for In Vivo Metabolism, P41-EB015908) at UT Southwestern, Dallas, TX, and La Ligue Contre le Cancer, La Region Centre, Agence Nationale de la Recherche (Lumzif ANR-12-BS07-0012, NIRA ANR-13-BS08-0011) grants at the Centre de Biophysique Mol{\'e}culaire, Orl{\'e}ans.",

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T2 - Efficient Dual MR/NIR Imaging Probes in Aqueous Medium

AU - Hashami, Zohreh

AU - Martins, Andre F.

AU - Funk, Alexander M.

AU - Jordan, Veronica Clavijo

AU - Petoud, Stéphane

AU - Eliseeva, Svetlana V.

AU - Kovacs, Zoltan

N1 - Funding Information: Lanthanide-based dual imaging probes have great potential, but there are several obstacles that must be overcome before they can be translated into practical biomedical applications. High in vivo stability is necessary to minimize toxicity. We ad- dressed this problem by using a ligand system based on DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), as these chelators form kinetically inert complexes. It is also desirable to shift the excitation wavelength above 600 nm to minimize absorption and scattering by biological tissue. This could be achieved by modifying the tropone chromophore. Who pays the bill for the research highlighted on the cover? This research was partly funded by a National Institutes of Health (NIH) Biotechnology Resource Grant (National Center for In Vivo Metabolism, P41-EB015908) at UT Southwestern, Dallas, TX, and La Ligue Contre le Cancer, La Region Centre, Agence Nationale de la Recherche (Lumzif ANR-12-BS07-0012, NIRA ANR-13-BS08-0011) grants at the Centre de Biophysique Moléculaire, Orléans.

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N2 - Invited for the cover of this issue are the groups of Zoltan Kovacs from the University of Texas Southwestern Medical Center, USA, and Svetlana Eliseeva from Centre de Biophysique Moléculaire, Orléans, France. The cover image shows the structure of a DOTA-based ligand, whose lanthanide complexes are useful imaging probes.

AB - Invited for the cover of this issue are the groups of Zoltan Kovacs from the University of Texas Southwestern Medical Center, USA, and Svetlana Eliseeva from Centre de Biophysique Moléculaire, Orléans, France. The cover image shows the structure of a DOTA-based ligand, whose lanthanide complexes are useful imaging probes.

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