Abstract

The insular cortex has been implicated as an important cortical site of cardiac regulation. It has been proposed that one insula may regulate cardiac parasympathetic activity while the other regulates sympathetic activity. Our purpose was to determine if hemispheric differences in insular activation exist for low and high intensity exercise using single photon emission computed to mography (SPECT) and magnetic resonance imaging (MRI). Four healthy men (24±2 yr) were studied during: seated rest; low intensity cycling (LIC); and high intensity cycling (HIC). For each condition, regional cerebral blood flow was measured via i.v. injection of 20mCi Tc99m-ECD (Neurolite). Individual SPECT and MRI data were aligned and percent changes in radioactivity from rest were calculated for each subject. Resting HR was 68 . During HIC (HR = 156±3 bpm), there was right insular activation (8.5±1.1%; P<0.05) with a trend for activation of the left (4.7±1.0%; P>0.05). These findings suggest that the left insula may be more involved in cardiac vagal withdrawal, while the right insula may be more involved in increased sympathetic activity during higher intensity exercise.

Original languageEnglish (US)
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997

Fingerprint

Magnetic resonance
Photons
magnetic resonance imaging
Cerebral Cortex
Cerebrovascular Circulation
cortex
exercise
Chemical activation
Magnetic Resonance Imaging
Exercise
Imaging techniques
Regional Blood Flow
Radioactivity
blood flow
Blood
injection
Injections
photons
technetium Tc 99m bicisate

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

@article{450ee7bfe2ae405aa1939aab3cad809a,
title = "Lateralization of insular cortex activation during high and low intensity exercise",
abstract = "The insular cortex has been implicated as an important cortical site of cardiac regulation. It has been proposed that one insula may regulate cardiac parasympathetic activity while the other regulates sympathetic activity. Our purpose was to determine if hemispheric differences in insular activation exist for low and high intensity exercise using single photon emission computed to mography (SPECT) and magnetic resonance imaging (MRI). Four healthy men (24±2 yr) were studied during: seated rest; low intensity cycling (LIC); and high intensity cycling (HIC). For each condition, regional cerebral blood flow was measured via i.v. injection of 20mCi Tc99m-ECD (Neurolite). Individual SPECT and MRI data were aligned and percent changes in radioactivity from rest were calculated for each subject. Resting HR was 68 . During HIC (HR = 156±3 bpm), there was right insular activation (8.5±1.1{\%}; P<0.05) with a trend for activation of the left (4.7±1.0{\%}; P>0.05). These findings suggest that the left insula may be more involved in cardiac vagal withdrawal, while the right insula may be more involved in increased sympathetic activity during higher intensity exercise.",
author = "Williamson, {J. W.} and R. McColl and D. Mathews and Mitchell, {J. H.}",
year = "1997",
language = "English (US)",
volume = "11",
journal = "FASEB Journal",
issn = "0892-6638",
publisher = "FASEB",
number = "3",

}

TY - JOUR

T1 - Lateralization of insular cortex activation during high and low intensity exercise

AU - Williamson, J. W.

AU - McColl, R.

AU - Mathews, D.

AU - Mitchell, J. H.

PY - 1997

Y1 - 1997

N2 - The insular cortex has been implicated as an important cortical site of cardiac regulation. It has been proposed that one insula may regulate cardiac parasympathetic activity while the other regulates sympathetic activity. Our purpose was to determine if hemispheric differences in insular activation exist for low and high intensity exercise using single photon emission computed to mography (SPECT) and magnetic resonance imaging (MRI). Four healthy men (24±2 yr) were studied during: seated rest; low intensity cycling (LIC); and high intensity cycling (HIC). For each condition, regional cerebral blood flow was measured via i.v. injection of 20mCi Tc99m-ECD (Neurolite). Individual SPECT and MRI data were aligned and percent changes in radioactivity from rest were calculated for each subject. Resting HR was 68 . During HIC (HR = 156±3 bpm), there was right insular activation (8.5±1.1%; P<0.05) with a trend for activation of the left (4.7±1.0%; P>0.05). These findings suggest that the left insula may be more involved in cardiac vagal withdrawal, while the right insula may be more involved in increased sympathetic activity during higher intensity exercise.

AB - The insular cortex has been implicated as an important cortical site of cardiac regulation. It has been proposed that one insula may regulate cardiac parasympathetic activity while the other regulates sympathetic activity. Our purpose was to determine if hemispheric differences in insular activation exist for low and high intensity exercise using single photon emission computed to mography (SPECT) and magnetic resonance imaging (MRI). Four healthy men (24±2 yr) were studied during: seated rest; low intensity cycling (LIC); and high intensity cycling (HIC). For each condition, regional cerebral blood flow was measured via i.v. injection of 20mCi Tc99m-ECD (Neurolite). Individual SPECT and MRI data were aligned and percent changes in radioactivity from rest were calculated for each subject. Resting HR was 68 . During HIC (HR = 156±3 bpm), there was right insular activation (8.5±1.1%; P<0.05) with a trend for activation of the left (4.7±1.0%; P>0.05). These findings suggest that the left insula may be more involved in cardiac vagal withdrawal, while the right insula may be more involved in increased sympathetic activity during higher intensity exercise.

UR - http://www.scopus.com/inward/record.url?scp=33750186231&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750186231&partnerID=8YFLogxK

M3 - Article

VL - 11

JO - FASEB Journal

JF - FASEB Journal

SN - 0892-6638

IS - 3

ER -