LCE

an open web portal to explore gene expression and clinical associations in lung cancer

Ling Cai, Shin Yi Lin, Luc Girard, Yunyun Zhou, Lin Yang, Bo Ci, Qinbo Zhou, Danni Luo, Bo Yao, Hao Tang, Jeffrey Allen, Kenneth Huffman, Adi F Gazdar, John Heymach, Ignacio Wistuba, Guanghua Xiao, John D Minna, Yang Xie

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We constructed a lung cancer-specific database housing expression data and clinical data from over 6700 patients in 56 studies. Expression data from 23 genome-wide platforms were carefully processed and quality controlled, whereas clinical data were standardized and rigorously curated. Empowered by this lung cancer database, we created an open access web resource—the Lung Cancer Explorer (LCE), which enables researchers and clinicians to explore these data and perform analyses. Users can perform meta-analyses on LCE to gain a quick overview of the results on tumor vs non-malignant tissue (normal) differential gene expression and expression-survival association. Individual dataset-based survival analysis, comparative analysis, and correlation analysis are also provided with flexible options to allow for customized analyses from the user.

Original languageEnglish (US)
JournalOncogene
DOIs
StateAccepted/In press - Jan 1 2018

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Lung Neoplasms
Gene Expression
Databases
Survival Analysis
Meta-Analysis
Research Personnel
Genome
Survival
Neoplasms

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

LCE : an open web portal to explore gene expression and clinical associations in lung cancer. / Cai, Ling; Lin, Shin Yi; Girard, Luc; Zhou, Yunyun; Yang, Lin; Ci, Bo; Zhou, Qinbo; Luo, Danni; Yao, Bo; Tang, Hao; Allen, Jeffrey; Huffman, Kenneth; Gazdar, Adi F; Heymach, John; Wistuba, Ignacio; Xiao, Guanghua; Minna, John D; Xie, Yang.

In: Oncogene, 01.01.2018.

Research output: Contribution to journalArticle

Cai, L, Lin, SY, Girard, L, Zhou, Y, Yang, L, Ci, B, Zhou, Q, Luo, D, Yao, B, Tang, H, Allen, J, Huffman, K, Gazdar, AF, Heymach, J, Wistuba, I, Xiao, G, Minna, JD & Xie, Y 2018, 'LCE: an open web portal to explore gene expression and clinical associations in lung cancer', Oncogene. https://doi.org/10.1038/s41388-018-0588-2
Cai, Ling ; Lin, Shin Yi ; Girard, Luc ; Zhou, Yunyun ; Yang, Lin ; Ci, Bo ; Zhou, Qinbo ; Luo, Danni ; Yao, Bo ; Tang, Hao ; Allen, Jeffrey ; Huffman, Kenneth ; Gazdar, Adi F ; Heymach, John ; Wistuba, Ignacio ; Xiao, Guanghua ; Minna, John D ; Xie, Yang. / LCE : an open web portal to explore gene expression and clinical associations in lung cancer. In: Oncogene. 2018.
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AU - Yang, Lin

AU - Ci, Bo

AU - Zhou, Qinbo

AU - Luo, Danni

AU - Yao, Bo

AU - Tang, Hao

AU - Allen, Jeffrey

AU - Huffman, Kenneth

AU - Gazdar, Adi F

AU - Heymach, John

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