LCE: an open web portal to explore gene expression and clinical associations in lung cancer

Ling Cai, Shin Yi Lin, Luc Girard, Yunyun Zhou, Lin Yang, Bo Ci, Qinbo Zhou, Danni Luo, Bo Yao, Hao Tang, Jeffrey Allen, Kenneth Huffman, Adi F Gazdar, John Heymach, Ignacio Wistuba, Guanghua Xiao, John D Minna, Yang Xie

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We constructed a lung cancer-specific database housing expression data and clinical data from over 6700 patients in 56 studies. Expression data from 23 genome-wide platforms were carefully processed and quality controlled, whereas clinical data were standardized and rigorously curated. Empowered by this lung cancer database, we created an open access web resource—the Lung Cancer Explorer (LCE), which enables researchers and clinicians to explore these data and perform analyses. Users can perform meta-analyses on LCE to gain a quick overview of the results on tumor vs non-malignant tissue (normal) differential gene expression and expression-survival association. Individual dataset-based survival analysis, comparative analysis, and correlation analysis are also provided with flexible options to allow for customized analyses from the user.

Original languageEnglish (US)
Pages (from-to)2551-2564
Number of pages14
JournalOncogene
Volume38
Issue number14
DOIs
StatePublished - Apr 4 2019

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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