LDL receptor-related proteins in neurodevelopment

Petra May, Joachim Herz

Research output: Contribution to journalReview article

44 Scopus citations

Abstract

Low-density lipoprotein receptor-related proteins (LRPs) are evolutionarily ancient cell-surface receptors with diverse biological functions. All are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family. Here, we will summarize recent advances in our understanding of the molecular basis on which these receptors function during development.

Original languageEnglish (US)
Pages (from-to)291-301
Number of pages11
JournalTraffic
Volume4
Issue number5
DOIs
StatePublished - May 1 2003

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Keywords

  • APP
  • Endocytosis
  • Gene transcription
  • LRP
  • Lipoprotein receptor
  • Neurodevelopment
  • Protein kinase
  • Reelin
  • Signal transduction
  • Wnt

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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