Leptin and cancer

From cancer stem cells to metastasis

Jiyoung Park, Philipp E. Scherer

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

There is growing evidence that obesity is a risk factor of cancer incidence and mortality. Hence, the identification of the mechanistic links between obesity and cancer progression is emerging as a topic of widespread interest. Recently, several groups have addressed the functional roles of leptin, an adipocyte-derived adipokine, for mammary tumor progression. In this issue of Endocrine-Related Cancer, Zheng et al. study the role of leptin on tumor growth in a xenograft model of MMTV-Wnt1-derived cancer cells. They study growth of these cancer cells in the context of obese animals, such as ob/ob mice (lacking leptin) and db/db mice (lacking functional leptin receptors (LEPR)) and find that leptin triggers LEPR-positive cancer stem cell differentiation, thereby promoting tumor cell survival. These findings highlight the therapeutic potential for leptin and leptin signaling in the context of mammary tumor growth.

Original languageEnglish (US)
JournalEndocrine-Related Cancer
Volume18
Issue number4
DOIs
StatePublished - Aug 2011

Fingerprint

Neoplastic Stem Cells
Leptin
Neoplasm Metastasis
Leptin Receptors
Neoplasms
Endocrine Gland Neoplasms
Growth
Obesity
Breast Neoplasms
Adipokines
Adipocytes
Heterografts
Cell Differentiation
Cell Survival
Mortality
Incidence

ASJC Scopus subject areas

  • Endocrinology
  • Oncology
  • Cancer Research
  • Endocrinology, Diabetes and Metabolism

Cite this

Leptin and cancer : From cancer stem cells to metastasis. / Park, Jiyoung; Scherer, Philipp E.

In: Endocrine-Related Cancer, Vol. 18, No. 4, 08.2011.

Research output: Contribution to journalArticle

@article{17f58e799f954699887c90a37e245e0b,
title = "Leptin and cancer: From cancer stem cells to metastasis",
abstract = "There is growing evidence that obesity is a risk factor of cancer incidence and mortality. Hence, the identification of the mechanistic links between obesity and cancer progression is emerging as a topic of widespread interest. Recently, several groups have addressed the functional roles of leptin, an adipocyte-derived adipokine, for mammary tumor progression. In this issue of Endocrine-Related Cancer, Zheng et al. study the role of leptin on tumor growth in a xenograft model of MMTV-Wnt1-derived cancer cells. They study growth of these cancer cells in the context of obese animals, such as ob/ob mice (lacking leptin) and db/db mice (lacking functional leptin receptors (LEPR)) and find that leptin triggers LEPR-positive cancer stem cell differentiation, thereby promoting tumor cell survival. These findings highlight the therapeutic potential for leptin and leptin signaling in the context of mammary tumor growth.",
author = "Jiyoung Park and Scherer, {Philipp E.}",
year = "2011",
month = "8",
doi = "10.1530/ERC-11-0163",
language = "English (US)",
volume = "18",
journal = "Endocrine-Related Cancer",
issn = "1351-0088",
publisher = "Society for Endocrinology",
number = "4",

}

TY - JOUR

T1 - Leptin and cancer

T2 - From cancer stem cells to metastasis

AU - Park, Jiyoung

AU - Scherer, Philipp E.

PY - 2011/8

Y1 - 2011/8

N2 - There is growing evidence that obesity is a risk factor of cancer incidence and mortality. Hence, the identification of the mechanistic links between obesity and cancer progression is emerging as a topic of widespread interest. Recently, several groups have addressed the functional roles of leptin, an adipocyte-derived adipokine, for mammary tumor progression. In this issue of Endocrine-Related Cancer, Zheng et al. study the role of leptin on tumor growth in a xenograft model of MMTV-Wnt1-derived cancer cells. They study growth of these cancer cells in the context of obese animals, such as ob/ob mice (lacking leptin) and db/db mice (lacking functional leptin receptors (LEPR)) and find that leptin triggers LEPR-positive cancer stem cell differentiation, thereby promoting tumor cell survival. These findings highlight the therapeutic potential for leptin and leptin signaling in the context of mammary tumor growth.

AB - There is growing evidence that obesity is a risk factor of cancer incidence and mortality. Hence, the identification of the mechanistic links between obesity and cancer progression is emerging as a topic of widespread interest. Recently, several groups have addressed the functional roles of leptin, an adipocyte-derived adipokine, for mammary tumor progression. In this issue of Endocrine-Related Cancer, Zheng et al. study the role of leptin on tumor growth in a xenograft model of MMTV-Wnt1-derived cancer cells. They study growth of these cancer cells in the context of obese animals, such as ob/ob mice (lacking leptin) and db/db mice (lacking functional leptin receptors (LEPR)) and find that leptin triggers LEPR-positive cancer stem cell differentiation, thereby promoting tumor cell survival. These findings highlight the therapeutic potential for leptin and leptin signaling in the context of mammary tumor growth.

UR - http://www.scopus.com/inward/record.url?scp=80052178858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052178858&partnerID=8YFLogxK

U2 - 10.1530/ERC-11-0163

DO - 10.1530/ERC-11-0163

M3 - Article

VL - 18

JO - Endocrine-Related Cancer

JF - Endocrine-Related Cancer

SN - 1351-0088

IS - 4

ER -