Lessons From the Laboratory

The Pathophysiology, and Consequences of Status Epilepticus

Karthik Rajasekaran, Santina A. Zanelli, Howard P. Goodkin

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Status epilepticus (SE) is the most common neurologic emergency of childhood. Experimental models parallel several clinical features of SE including (1) treatment is complicated by an increasing probability that benzodiazepines will fail with increasing seizure duration and (2) outcome varies with age and etiology. Studies using these models showed that the activity-dependent trafficking of GABAA receptors contributes in part to the progressive decline in GABA-mediated inhibition and the failure of the benzodiazepines. Furthermore, laboratory studies have provided evidence that age and inciting stimulus interact to determine the neuronal circuits activated during SE (ie, functional anatomy) and that differences in functional anatomy can partially account for variations in SE outcome. Future laboratory studies are likely to provide an additional understanding of the cellular and molecular mechanisms that underlie SE and its consequences. Such studies are necessary in the development of rational emergent therapy for SE and its long-term outcomes.

Original languageEnglish (US)
Pages (from-to)136-143
Number of pages8
JournalSeminars in Pediatric Neurology
Volume17
Issue number3
DOIs
StatePublished - Sep 2010

Fingerprint

Status Epilepticus
Benzodiazepines
Anatomy
GABA-A Receptors
gamma-Aminobutyric Acid
Nervous System
Seizures
Emergencies
Theoretical Models

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Lessons From the Laboratory : The Pathophysiology, and Consequences of Status Epilepticus. / Rajasekaran, Karthik; Zanelli, Santina A.; Goodkin, Howard P.

In: Seminars in Pediatric Neurology, Vol. 17, No. 3, 09.2010, p. 136-143.

Research output: Contribution to journalArticle

Rajasekaran, Karthik ; Zanelli, Santina A. ; Goodkin, Howard P. / Lessons From the Laboratory : The Pathophysiology, and Consequences of Status Epilepticus. In: Seminars in Pediatric Neurology. 2010 ; Vol. 17, No. 3. pp. 136-143.
@article{13b5d1a2d1b346d99305c8c3dc25b341,
title = "Lessons From the Laboratory: The Pathophysiology, and Consequences of Status Epilepticus",
abstract = "Status epilepticus (SE) is the most common neurologic emergency of childhood. Experimental models parallel several clinical features of SE including (1) treatment is complicated by an increasing probability that benzodiazepines will fail with increasing seizure duration and (2) outcome varies with age and etiology. Studies using these models showed that the activity-dependent trafficking of GABAA receptors contributes in part to the progressive decline in GABA-mediated inhibition and the failure of the benzodiazepines. Furthermore, laboratory studies have provided evidence that age and inciting stimulus interact to determine the neuronal circuits activated during SE (ie, functional anatomy) and that differences in functional anatomy can partially account for variations in SE outcome. Future laboratory studies are likely to provide an additional understanding of the cellular and molecular mechanisms that underlie SE and its consequences. Such studies are necessary in the development of rational emergent therapy for SE and its long-term outcomes.",
author = "Karthik Rajasekaran and Zanelli, {Santina A.} and Goodkin, {Howard P.}",
year = "2010",
month = "9",
doi = "10.1016/j.spen.2010.06.002",
language = "English (US)",
volume = "17",
pages = "136--143",
journal = "Seminars in Pediatric Neurology",
issn = "1071-9091",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Lessons From the Laboratory

T2 - The Pathophysiology, and Consequences of Status Epilepticus

AU - Rajasekaran, Karthik

AU - Zanelli, Santina A.

AU - Goodkin, Howard P.

PY - 2010/9

Y1 - 2010/9

N2 - Status epilepticus (SE) is the most common neurologic emergency of childhood. Experimental models parallel several clinical features of SE including (1) treatment is complicated by an increasing probability that benzodiazepines will fail with increasing seizure duration and (2) outcome varies with age and etiology. Studies using these models showed that the activity-dependent trafficking of GABAA receptors contributes in part to the progressive decline in GABA-mediated inhibition and the failure of the benzodiazepines. Furthermore, laboratory studies have provided evidence that age and inciting stimulus interact to determine the neuronal circuits activated during SE (ie, functional anatomy) and that differences in functional anatomy can partially account for variations in SE outcome. Future laboratory studies are likely to provide an additional understanding of the cellular and molecular mechanisms that underlie SE and its consequences. Such studies are necessary in the development of rational emergent therapy for SE and its long-term outcomes.

AB - Status epilepticus (SE) is the most common neurologic emergency of childhood. Experimental models parallel several clinical features of SE including (1) treatment is complicated by an increasing probability that benzodiazepines will fail with increasing seizure duration and (2) outcome varies with age and etiology. Studies using these models showed that the activity-dependent trafficking of GABAA receptors contributes in part to the progressive decline in GABA-mediated inhibition and the failure of the benzodiazepines. Furthermore, laboratory studies have provided evidence that age and inciting stimulus interact to determine the neuronal circuits activated during SE (ie, functional anatomy) and that differences in functional anatomy can partially account for variations in SE outcome. Future laboratory studies are likely to provide an additional understanding of the cellular and molecular mechanisms that underlie SE and its consequences. Such studies are necessary in the development of rational emergent therapy for SE and its long-term outcomes.

UR - http://www.scopus.com/inward/record.url?scp=77955786578&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955786578&partnerID=8YFLogxK

U2 - 10.1016/j.spen.2010.06.002

DO - 10.1016/j.spen.2010.06.002

M3 - Article

VL - 17

SP - 136

EP - 143

JO - Seminars in Pediatric Neurology

JF - Seminars in Pediatric Neurology

SN - 1071-9091

IS - 3

ER -