Lessons in hypertension from new clinical trials

Research output: Contribution to journalArticle

Abstract

Three important principles have emerged from recent epidemiologic and clinical studies in hypertension. First, patients with hypertension most often have other cardiovascular risk factors such as obesity and diabetes. Second, hypertension remains grossly undertreated. Third, at blood pressure levels once considered "high-normal," early organ damage may already be taking place in patients with multiple risk factors that, without treatment, can eventually lead to cardiovascular morbidity and mortality. The concept of evaluating global or overall risk is gaining wide acceptance, and US treatment guidelines may soon reflect these findings and assist clinicians in identifying individuals who are most likely to benefit from therapy. Results from clinical trials suggest that among the various pharmacologic agents available to treat hypertension, blockers of the renin-angiotensin system are effective in type 2 diabetes and chronic kidney disease, conditions that often occur in conjunction with hypertension.

Original languageEnglish (US)
Pages (from-to)34-43
Number of pages10
JournalPostgraduate Medicine
Volume121
Issue number6
DOIs
StatePublished - Nov 2009

Fingerprint

Clinical Trials
Hypertension
Renin-Angiotensin System
Chronic Renal Insufficiency
Type 2 Diabetes Mellitus
Epidemiologic Studies
Therapeutics
Obesity
Guidelines
Blood Pressure
Morbidity
Mortality

Keywords

  • Angiotensin receptor blockers
  • Cardiovascular disease
  • Hypertension
  • Reninangiotensin system
  • Treatment guidelines

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lessons in hypertension from new clinical trials. / Nesbitt, Shawna D.

In: Postgraduate Medicine, Vol. 121, No. 6, 11.2009, p. 34-43.

Research output: Contribution to journalArticle

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