Lessons Learned from a Decade of Multicenter Cooperative Clinical Trials in Stress Urinary Incontinence

Benjamin E. Dillon, Dominic Lee, Gary E. Lemack

Research output: Contribution to journalReview article

Abstract

Stress urinary incontinence (SUI) is estimated to affect 12 % to 55 % of women at some point in their life. Furthermore, 15 % to 35 % of adult American women report that their quality of life is altered by urinary incontinence. In addition to the toll SUI takes on patient lives-physically, socially and psychologically-it also comes at a significant cost to health care systems. In 1999, as an initiative of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Institute of Child Health and Human Development (NICHD), the Urinary Incontinence Treatment Network (UITN) was born, with the primary task of developing trials to evaluate treatment of urinary incontinence in women. The purpose of this article is to review the SUI trials conducted and challenges faced, and to highlight the lessons learned from a decade of UITN work.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalCurrent Bladder Dysfunction Reports
Volume7
Issue number3
DOIs
StatePublished - Dec 1 2012

Keywords

  • Clinical trials
  • SISTEr
  • Stress incontinence
  • Stress urinary incontinence
  • TOMUS
  • UITN
  • Urinary Incontinence Treatment Network
  • Urodynamics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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