Leukemic transdifferentiation of follicular lymphoma into an acute histiocytic leukemia in a 52-year-old Caucasian woman

Bryan Steussy, Jacqueline Lekostaj, Qining Qian, Nancy Rosenthal, Carol J. Holman, Sergei Syrbu, Benjamin Darbro, Aaron Bossler, Nitin J. Karandikar

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We report an instructive case of acute myeloid leukemia with histiocytic differentiation (acute histiocytic leukemia) arising in a patient, a 52-year-old woman with a history of follicular lymphoma. The results of genetic studies proved a clonal relationship between the lymphoma and the leukemic cells. To our knowledge, this is the first report of leukemic transdifferentiation of follicular lymphoma into modified base 5-methylcytosine (M (M5c)-like acute histiocytic leukemia and the first reported karyotype on a transdifferentiated neoplasm.

Original languageEnglish (US)
Pages (from-to)155-157
Number of pages3
JournalLaboratory Medicine
Volume47
Issue number2
DOIs
StatePublished - 2016

Fingerprint

5-Methylcytosine
Follicular Lymphoma
Leukemia
Karyotype
Acute Myeloid Leukemia
Lymphoma
Neoplasms

Keywords

  • B cell
  • Histiocytic
  • Leukemia
  • Lymphoma
  • Sarcoma
  • Transdifferentiation

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Steussy, B., Lekostaj, J., Qian, Q., Rosenthal, N., Holman, C. J., Syrbu, S., ... Karandikar, N. J. (2016). Leukemic transdifferentiation of follicular lymphoma into an acute histiocytic leukemia in a 52-year-old Caucasian woman. Laboratory Medicine, 47(2), 155-157. https://doi.org/10.1093/labmed/lmw011

Leukemic transdifferentiation of follicular lymphoma into an acute histiocytic leukemia in a 52-year-old Caucasian woman. / Steussy, Bryan; Lekostaj, Jacqueline; Qian, Qining; Rosenthal, Nancy; Holman, Carol J.; Syrbu, Sergei; Darbro, Benjamin; Bossler, Aaron; Karandikar, Nitin J.

In: Laboratory Medicine, Vol. 47, No. 2, 2016, p. 155-157.

Research output: Contribution to journalArticle

Steussy, B, Lekostaj, J, Qian, Q, Rosenthal, N, Holman, CJ, Syrbu, S, Darbro, B, Bossler, A & Karandikar, NJ 2016, 'Leukemic transdifferentiation of follicular lymphoma into an acute histiocytic leukemia in a 52-year-old Caucasian woman', Laboratory Medicine, vol. 47, no. 2, pp. 155-157. https://doi.org/10.1093/labmed/lmw011
Steussy, Bryan ; Lekostaj, Jacqueline ; Qian, Qining ; Rosenthal, Nancy ; Holman, Carol J. ; Syrbu, Sergei ; Darbro, Benjamin ; Bossler, Aaron ; Karandikar, Nitin J. / Leukemic transdifferentiation of follicular lymphoma into an acute histiocytic leukemia in a 52-year-old Caucasian woman. In: Laboratory Medicine. 2016 ; Vol. 47, No. 2. pp. 155-157.
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