Leukemic transdifferentiation of follicular lymphoma into an acute histiocytic leukemia in a 52-year-old Caucasian woman

Bryan Steussy; Jacqueline Lekostaj; Qining Qian; Nancy Rosenthal; Carol J. Holman; Sergei Syrbu; Benjamin Darbro; Aaron Bossler; Nitin J. Karandikar

doi:10.1093/labmed/lmw011

Leukemic transdifferentiation of follicular lymphoma into an acute histiocytic leukemia in a 52-year-old Caucasian woman

Bryan Steussy, Jacqueline Lekostaj, Qining Qian, Nancy Rosenthal, Carol J. Holman, Sergei Syrbu, Benjamin Darbro, Aaron Bossler, Nitin J. Karandikar

Pathology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We report an instructive case of acute myeloid leukemia with histiocytic differentiation (acute histiocytic leukemia) arising in a patient, a 52-year-old woman with a history of follicular lymphoma. The results of genetic studies proved a clonal relationship between the lymphoma and the leukemic cells. To our knowledge, this is the first report of leukemic transdifferentiation of follicular lymphoma into modified base 5-methylcytosine (M (M⁵c)-like acute histiocytic leukemia and the first reported karyotype on a transdifferentiated neoplasm.

Original language	English (US)
Pages (from-to)	155-157
Number of pages	3
Journal	Lab Medicine
Volume	47
Issue number	2
DOIs	https://doi.org/10.1093/labmed/lmw011
State	Published - May 1 2016

Keywords

B cell
Histiocytic
Leukemia
Lymphoma
Sarcoma
Transdifferentiation

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical

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10.1093/labmed/lmw011

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title = "Leukemic transdifferentiation of follicular lymphoma into an acute histiocytic leukemia in a 52-year-old Caucasian woman",

abstract = "We report an instructive case of acute myeloid leukemia with histiocytic differentiation (acute histiocytic leukemia) arising in a patient, a 52-year-old woman with a history of follicular lymphoma. The results of genetic studies proved a clonal relationship between the lymphoma and the leukemic cells. To our knowledge, this is the first report of leukemic transdifferentiation of follicular lymphoma into modified base 5-methylcytosine (M (M5c)-like acute histiocytic leukemia and the first reported karyotype on a transdifferentiated neoplasm.",

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AU - Steussy, Bryan

AU - Lekostaj, Jacqueline

AU - Qian, Qining

AU - Rosenthal, Nancy

AU - Holman, Carol J.

AU - Syrbu, Sergei

AU - Darbro, Benjamin

AU - Bossler, Aaron

AU - Karandikar, Nitin J.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - We report an instructive case of acute myeloid leukemia with histiocytic differentiation (acute histiocytic leukemia) arising in a patient, a 52-year-old woman with a history of follicular lymphoma. The results of genetic studies proved a clonal relationship between the lymphoma and the leukemic cells. To our knowledge, this is the first report of leukemic transdifferentiation of follicular lymphoma into modified base 5-methylcytosine (M (M5c)-like acute histiocytic leukemia and the first reported karyotype on a transdifferentiated neoplasm.

AB - We report an instructive case of acute myeloid leukemia with histiocytic differentiation (acute histiocytic leukemia) arising in a patient, a 52-year-old woman with a history of follicular lymphoma. The results of genetic studies proved a clonal relationship between the lymphoma and the leukemic cells. To our knowledge, this is the first report of leukemic transdifferentiation of follicular lymphoma into modified base 5-methylcytosine (M (M5c)-like acute histiocytic leukemia and the first reported karyotype on a transdifferentiated neoplasm.

KW - B cell

KW - Histiocytic

KW - Leukemia

KW - Lymphoma

KW - Sarcoma

KW - Transdifferentiation

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Leukemic transdifferentiation of follicular lymphoma into an acute histiocytic leukemia in a 52-year-old Caucasian woman

Abstract

Keywords

ASJC Scopus subject areas

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