Leukemic transdifferentiation of follicular lymphoma into an acute histiocytic leukemia in a 52-year-old Caucasian woman

Bryan Steussy, Jacqueline Lekostaj, Qining Qian, Nancy Rosenthal, Carol J. Holman, Sergei Syrbu, Benjamin Darbro, Aaron Bossler, Nitin J. Karandikar

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

We report an instructive case of acute myeloid leukemia with histiocytic differentiation (acute histiocytic leukemia) arising in a patient, a 52-year-old woman with a history of follicular lymphoma. The results of genetic studies proved a clonal relationship between the lymphoma and the leukemic cells. To our knowledge, this is the first report of leukemic transdifferentiation of follicular lymphoma into modified base 5-methylcytosine (M (M5c)-like acute histiocytic leukemia and the first reported karyotype on a transdifferentiated neoplasm.

Original languageEnglish (US)
Pages (from-to)155-157
Number of pages3
JournalLab Medicine
Volume47
Issue number2
DOIs
StatePublished - May 1 2016

Keywords

  • B cell
  • Histiocytic
  • Leukemia
  • Lymphoma
  • Sarcoma
  • Transdifferentiation

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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