Lichen Sclerosus: Review of the Literature and Current Recommendations for Management

Jennifer M. Pugliese, Allen F. Morey, Andrew C. Peterson

Research output: Contribution to journalArticle

182 Citations (Scopus)

Abstract

Purpose: We reviewed the literature regarding the clinical presentation, etiology, natural history, and medical and surgical management of lichen sclerosus in men. Materials and Methods: We performed a comprehensive search of the literature in PubMed, MEDLINE® and other electronic databases between 1950 and 2006 using the key words lichen sclerosis, balanitis xerotica obliterans and urethral stricture. Our search resulted in 1,268 sources containing the words lichen sclerosus or balanitis xerotica obliterans. We reviewed 68 articles in the peer reviewed journals and 2 chapters on this subject. Results: Lichen sclerosus is a chronic, lymphocyte mediated skin disease that was first described in 1887. It shows a predilection for the anogenital area in men and women. Much has been discovered regarding the epidemiology, natural history and histological features of this disease process during the last century, including the discovery of a strong association between lichen sclerosus and squamous cell carcinoma. The techniques of medical and surgical management of this disorder are still being elucidated. Biopsy of the initial lesion for definitive diagnosis and long-term followup of affected patients are well established, critical elements in the management of lichen sclerosus. Conclusions: Lichen sclerosus is a chronic, debilitating condition that may progress to cause significant voiding complications. Biopsy is recommended in all patients suspected of having lichen sclerosus to rule out squamous cell carcinoma. Further research is needed to improve the prevention, understanding and treatment of this challenging condition.

Original languageEnglish (US)
Pages (from-to)2268-2276
Number of pages9
JournalJournal of Urology
Volume178
Issue number6
DOIs
StatePublished - Dec 2007

Fingerprint

Lichen Sclerosus et Atrophicus
Balanitis Xerotica Obliterans
Natural History
Squamous Cell Carcinoma
Biopsy
Urethral Stricture
Skin Diseases
PubMed
MEDLINE
Epidemiology
Databases
Lymphocytes

Keywords

  • balanitis xerotica obliterans
  • lichen sclerosus et atrophicus
  • urethral stricture

ASJC Scopus subject areas

  • Urology

Cite this

Lichen Sclerosus : Review of the Literature and Current Recommendations for Management. / Pugliese, Jennifer M.; Morey, Allen F.; Peterson, Andrew C.

In: Journal of Urology, Vol. 178, No. 6, 12.2007, p. 2268-2276.

Research output: Contribution to journalArticle

Pugliese, Jennifer M. ; Morey, Allen F. ; Peterson, Andrew C. / Lichen Sclerosus : Review of the Literature and Current Recommendations for Management. In: Journal of Urology. 2007 ; Vol. 178, No. 6. pp. 2268-2276.
@article{51e6908f14e34cedb79ad5ed2e78365a,
title = "Lichen Sclerosus: Review of the Literature and Current Recommendations for Management",
abstract = "Purpose: We reviewed the literature regarding the clinical presentation, etiology, natural history, and medical and surgical management of lichen sclerosus in men. Materials and Methods: We performed a comprehensive search of the literature in PubMed, MEDLINE{\circledR} and other electronic databases between 1950 and 2006 using the key words lichen sclerosis, balanitis xerotica obliterans and urethral stricture. Our search resulted in 1,268 sources containing the words lichen sclerosus or balanitis xerotica obliterans. We reviewed 68 articles in the peer reviewed journals and 2 chapters on this subject. Results: Lichen sclerosus is a chronic, lymphocyte mediated skin disease that was first described in 1887. It shows a predilection for the anogenital area in men and women. Much has been discovered regarding the epidemiology, natural history and histological features of this disease process during the last century, including the discovery of a strong association between lichen sclerosus and squamous cell carcinoma. The techniques of medical and surgical management of this disorder are still being elucidated. Biopsy of the initial lesion for definitive diagnosis and long-term followup of affected patients are well established, critical elements in the management of lichen sclerosus. Conclusions: Lichen sclerosus is a chronic, debilitating condition that may progress to cause significant voiding complications. Biopsy is recommended in all patients suspected of having lichen sclerosus to rule out squamous cell carcinoma. Further research is needed to improve the prevention, understanding and treatment of this challenging condition.",
keywords = "balanitis xerotica obliterans, lichen sclerosus et atrophicus, urethral stricture",
author = "Pugliese, {Jennifer M.} and Morey, {Allen F.} and Peterson, {Andrew C.}",
year = "2007",
month = "12",
doi = "10.1016/j.juro.2007.08.024",
language = "English (US)",
volume = "178",
pages = "2268--2276",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Lichen Sclerosus

T2 - Review of the Literature and Current Recommendations for Management

AU - Pugliese, Jennifer M.

AU - Morey, Allen F.

AU - Peterson, Andrew C.

PY - 2007/12

Y1 - 2007/12

N2 - Purpose: We reviewed the literature regarding the clinical presentation, etiology, natural history, and medical and surgical management of lichen sclerosus in men. Materials and Methods: We performed a comprehensive search of the literature in PubMed, MEDLINE® and other electronic databases between 1950 and 2006 using the key words lichen sclerosis, balanitis xerotica obliterans and urethral stricture. Our search resulted in 1,268 sources containing the words lichen sclerosus or balanitis xerotica obliterans. We reviewed 68 articles in the peer reviewed journals and 2 chapters on this subject. Results: Lichen sclerosus is a chronic, lymphocyte mediated skin disease that was first described in 1887. It shows a predilection for the anogenital area in men and women. Much has been discovered regarding the epidemiology, natural history and histological features of this disease process during the last century, including the discovery of a strong association between lichen sclerosus and squamous cell carcinoma. The techniques of medical and surgical management of this disorder are still being elucidated. Biopsy of the initial lesion for definitive diagnosis and long-term followup of affected patients are well established, critical elements in the management of lichen sclerosus. Conclusions: Lichen sclerosus is a chronic, debilitating condition that may progress to cause significant voiding complications. Biopsy is recommended in all patients suspected of having lichen sclerosus to rule out squamous cell carcinoma. Further research is needed to improve the prevention, understanding and treatment of this challenging condition.

AB - Purpose: We reviewed the literature regarding the clinical presentation, etiology, natural history, and medical and surgical management of lichen sclerosus in men. Materials and Methods: We performed a comprehensive search of the literature in PubMed, MEDLINE® and other electronic databases between 1950 and 2006 using the key words lichen sclerosis, balanitis xerotica obliterans and urethral stricture. Our search resulted in 1,268 sources containing the words lichen sclerosus or balanitis xerotica obliterans. We reviewed 68 articles in the peer reviewed journals and 2 chapters on this subject. Results: Lichen sclerosus is a chronic, lymphocyte mediated skin disease that was first described in 1887. It shows a predilection for the anogenital area in men and women. Much has been discovered regarding the epidemiology, natural history and histological features of this disease process during the last century, including the discovery of a strong association between lichen sclerosus and squamous cell carcinoma. The techniques of medical and surgical management of this disorder are still being elucidated. Biopsy of the initial lesion for definitive diagnosis and long-term followup of affected patients are well established, critical elements in the management of lichen sclerosus. Conclusions: Lichen sclerosus is a chronic, debilitating condition that may progress to cause significant voiding complications. Biopsy is recommended in all patients suspected of having lichen sclerosus to rule out squamous cell carcinoma. Further research is needed to improve the prevention, understanding and treatment of this challenging condition.

KW - balanitis xerotica obliterans

KW - lichen sclerosus et atrophicus

KW - urethral stricture

UR - http://www.scopus.com/inward/record.url?scp=35748951288&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35748951288&partnerID=8YFLogxK

U2 - 10.1016/j.juro.2007.08.024

DO - 10.1016/j.juro.2007.08.024

M3 - Article

C2 - 17936829

AN - SCOPUS:35748951288

VL - 178

SP - 2268

EP - 2276

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 6

ER -