TY - JOUR
T1 - Lifetime risks for cardiovascular disease mortality by cardiorespiratory fitness levels measured at ages 45, 55, and 65 years in men
T2 - The cooper center longitudinal study
AU - Berry, Jarett D
AU - Willis, Benjamin
AU - Gupta, Sachin
AU - Barlow, Carolyn E.
AU - Lakoski, Susan G.
AU - Khera, Amit
AU - Rohatgi, Anand K
AU - de Lemos, James A
AU - Haskell, William
AU - Lloyd-Jones, Donald M.
N1 - Funding Information:
Analyses for the Lifetime Risk Pooling Project were supported by grant R21 HL085375 from the National Heart, Lung, and Blood Institute (Primary Investigator: Dr. Lloyd-Jones). Dr. Berry receives funding from the Dedman Family Scholar in Clinical Care Endowment at University of Texas Southwestern Medical Center, grant K23 HL092229 from the National Heart, Lung, and Blood Institute , and grant 10BG1A4280091 from the American Heart Association . Dr. Berry has received honoraria from Merck/Schering and served on the Speakers' Bureau of Merck. Dr. Khera reports a consulting relationship with Daiichi-Sankyo. All other authors have reported that they have no relationships to disclose.
PY - 2011/4/5
Y1 - 2011/4/5
N2 - Objectives: The purpose of this study was to determine the association between fitness and lifetime risk for cardiovascular disease (CVD). Background: Higher levels of traditional risk factors are associated with marked differences in lifetime risks for CVD. However, data are sparse regarding the association between fitness and the lifetime risk for CVD. Methods: We followed up 11,049 men who underwent clinical examination at the Cooper Institute in Dallas, Texas, before 1990 until the occurrence of CVD death, non-CVD death, or attainment of age 90 years (281,469 person-years of follow-up, median follow-up 25.3 years, 1,106 CVD deaths). Fitness was measured by the Balke protocol and categorized according to treadmill time into low, moderate, and high fitness, with further stratification by CVD risk factor burden. Lifetime risk for CVD death determined by the National Death Index was estimated for fitness levels measured at ages 45, 55, and 65 years, with non-CVD death as the competing event. Results: Differences in fitness levels (low fitness vs. high fitness) were associated with marked differences in the lifetime risks for CVD death at each index age: age 45 years, 13.7% versus 3.4%; age 55 years, 34.2% versus 15.3%; and age 65 years, 35.6% versus 17.1%. These associations were strongest among persons with CVD risk factors. Conclusions: A single measurement of low fitness in mid-life was associated with higher lifetime risk for CVD death, particularly among persons with a high burden of CVD risk factors.
AB - Objectives: The purpose of this study was to determine the association between fitness and lifetime risk for cardiovascular disease (CVD). Background: Higher levels of traditional risk factors are associated with marked differences in lifetime risks for CVD. However, data are sparse regarding the association between fitness and the lifetime risk for CVD. Methods: We followed up 11,049 men who underwent clinical examination at the Cooper Institute in Dallas, Texas, before 1990 until the occurrence of CVD death, non-CVD death, or attainment of age 90 years (281,469 person-years of follow-up, median follow-up 25.3 years, 1,106 CVD deaths). Fitness was measured by the Balke protocol and categorized according to treadmill time into low, moderate, and high fitness, with further stratification by CVD risk factor burden. Lifetime risk for CVD death determined by the National Death Index was estimated for fitness levels measured at ages 45, 55, and 65 years, with non-CVD death as the competing event. Results: Differences in fitness levels (low fitness vs. high fitness) were associated with marked differences in the lifetime risks for CVD death at each index age: age 45 years, 13.7% versus 3.4%; age 55 years, 34.2% versus 15.3%; and age 65 years, 35.6% versus 17.1%. These associations were strongest among persons with CVD risk factors. Conclusions: A single measurement of low fitness in mid-life was associated with higher lifetime risk for CVD death, particularly among persons with a high burden of CVD risk factors.
KW - cardiovascular disease
KW - epidemiology
KW - exercise testing
KW - lifetime risk
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U2 - 10.1016/j.jacc.2010.10.056
DO - 10.1016/j.jacc.2010.10.056
M3 - Article
C2 - 21474041
AN - SCOPUS:79953721665
SN - 0735-1097
VL - 57
SP - 1604
EP - 1610
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 15
ER -