Lipodystrophy Syndromes

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations

Abstract

Lipodystrophies are heterogeneous disorders characterized by varying degrees of body fat loss and predisposition to insulin resistance and its metabolic complications. They are subclassified depending on degree of fat loss and whether the disorder is genetic or acquired. The two most common genetic varieties include congenital generalized lipodystrophy and familial partial lipodystrophy; the two most common acquired varieties include acquired generalized lipodystrophy and acquired partial lipodystrophy. Highly active antiretroviral therapy–induced lipodystrophy in patients infected with human immunodeficiency virus and drug-induced localized lipodystrophy are common subtypes. The metabolic abnormalities associated with lipodystrophy include insulin resistance, hypertriglyceridemia, and hepatic steatosis. Management focuses on preventing and treating metabolic complications.

Original languageEnglish (US)
Pages (from-to)783-797
Number of pages15
JournalEndocrinology and Metabolism Clinics of North America
Volume45
Issue number4
DOIs
StatePublished - Dec 1 2016

Keywords

  • Acquired generalized lipodystrophy
  • Acquired partial lipodystrophy
  • Congenital generalized lipodystrophy
  • Familial partial lipodystrophy
  • Lipodystrophy
  • Metreleptin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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