TY - JOUR
T1 - Liver X receptor signaling pathways in cardiovascular disease
AU - Tontonoz, Peter
AU - Mangelsdorf, David J.
PY - 2003/6/1
Y1 - 2003/6/1
N2 - The liver X receptors α and β (LXRα and LXRβ) are members of the nuclear receptor family of proteins that are critical for the control of lipid homeostasis in vertebrates. The endogenous activators of these receptors are oxysterols and intermediates in the cholesterol biosynthetic pathway. LXRs serve as cholesterol sensors that regulate the expression of multiple genes involved in the efflux, transport, and excretion of cholesterol. Recent studies have outlined the importance of LXR signaling pathways in the development of metabolic disorders such as hyperlipidemia and atherosclerosis. Synthetic LXR agonists inhibit the development of atherosclerosis in murine models, an effect that is likely to result from the modulation of both metabolic and inflammatory gene expression. These observations identify the LXR pathway as a potential target for therapeutic intervention in human cardiovascular disease.
AB - The liver X receptors α and β (LXRα and LXRβ) are members of the nuclear receptor family of proteins that are critical for the control of lipid homeostasis in vertebrates. The endogenous activators of these receptors are oxysterols and intermediates in the cholesterol biosynthetic pathway. LXRs serve as cholesterol sensors that regulate the expression of multiple genes involved in the efflux, transport, and excretion of cholesterol. Recent studies have outlined the importance of LXR signaling pathways in the development of metabolic disorders such as hyperlipidemia and atherosclerosis. Synthetic LXR agonists inhibit the development of atherosclerosis in murine models, an effect that is likely to result from the modulation of both metabolic and inflammatory gene expression. These observations identify the LXR pathway as a potential target for therapeutic intervention in human cardiovascular disease.
UR - http://www.scopus.com/inward/record.url?scp=0037503924&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037503924&partnerID=8YFLogxK
U2 - 10.1210/me.2003-0061
DO - 10.1210/me.2003-0061
M3 - Short survey
C2 - 12690094
AN - SCOPUS:0037503924
SN - 0888-8809
VL - 17
SP - 985
EP - 993
JO - Molecular Endocrinology
JF - Molecular Endocrinology
IS - 6
ER -