Liver X receptors as therapeutic targets for managing cholesterol: Implications for inflammatory conditions

Yuan Zhang, Jessica F. Chan, Carolyn L. Cummins

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Atherosclerosis is a disease characterized by excess cholesterol and inflammation in the blood vessels. The liver X receptors (α and β) are members of the nuclear hormone receptor family that are activated by endogenous cholesterol metabolites. These receptors are widely expressed with a tissue distribution that includes the liver, intestine and macrophage. Upon activation, these receptors have been shown to increase reverse cholesterol transport from the macrophage back to the liver to aid in the removal of excess cholesterol. More recently, they have also been shown to inhibit the inflammatory response in macrophages. These functions are accomplished through direct regulation of gene transcription. Herein, we will describe the key benefits and potential risks of targeting the liver X receptors for the treatment of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)29-40
Number of pages12
JournalFuture Lipidology
Volume4
Issue number1
DOIs
StatePublished - Jun 19 2009

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Keywords

  • ABCA1
  • Adrenal gland
  • Atherosderosis
  • Brain
  • Cholesterol
  • Inflammation
  • LXR
  • Liver
  • Lung
  • Reverse cholesterol transport
  • SREBP-1c

ASJC Scopus subject areas

  • Biochemistry

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