Livestock pluripotency is finally captured in vitro

Micaela Navarro, Delia A. Soto, Carlos A. Pinzon, Jun Wu, Pablo J. Ross

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Pluripotent stem cells (PSCs) have demonstrated great utility in improving our understanding of mammalian development and continue to revolutionise regenerative medicine. Thanks to the improved understanding of pluripotency in mice and humans, it has recently become feasible to generate stable livestock PSCs. Although it is unlikely that livestock PSCs will be used for similar applications as their murine and human counterparts, new exciting applications that could greatly advance animal agriculture are being developed, including the use of PSCs for complex genome editing, cellular agriculture, gamete generation and in vitro breeding schemes.

Original languageEnglish (US)
Pages (from-to)11-39
Number of pages29
JournalReproduction, Fertility and Development
Volume32
Issue number2
DOIs
StatePublished - Dec 2 2019

Keywords

  • Wingless/Integrated (WNT) signaling pathway
  • cattle
  • embryo
  • embryonic stem cells
  • induced pluripotent stem cells
  • inhibitor of Wnt response (IWR)-1
  • pig
  • tankyrase

ASJC Scopus subject areas

  • Biotechnology
  • Reproductive Medicine
  • Animal Science and Zoology
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Developmental Biology

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