Living Donor Uterus Transplantation: A Single Center's Observations and Lessons Learned From Early Setbacks to Technical Success

G. Testa, E. C. Koon, L. Johannesson, G. J. McKenna, T. Anthony, G. B. Klintmalm, R. T. Gunby, A. M. Warren, J. M. Putman, G. dePrisco, J. M. Mitchell, K. Wallis, M. Olausson

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

Uterus transplantation is a vascularized composite allograft transplantation. It allows women who do not have a uterus to become pregnant and deliver a baby. In this paper, we analyze the first five cases of living donor uterus transplantation performed in the United States. The first three recipients lost their uterus grafts at days 14, 12, and 6, respectively, after transplant. Vascular complications, related to both inflow and outflow problems, were identified as the primary reason for the graft losses. Two recipients, at 6 and 3 mo, respectively, after transplant, have functioning grafts with regular menstrual cycles. Ultimate success will be claimed only after a live birth. This paper is an in-depth analysis of evaluation, surgical technique, and follow-up of these five living donor uterus transplants. The lessons learned were instrumental in allowing us to evolve from failure to technical and functional success. We aim to share our conclusions and build on knowledge in the evolving field of uterus transplantation.

Original languageEnglish (US)
Pages (from-to)2901-2910
Number of pages10
JournalAmerican Journal of Transplantation
Volume17
Issue number11
DOIs
StatePublished - Nov 2017
Externally publishedYes

Keywords

  • clinical research/practice
  • donors and donation: living
  • surgical technique
  • vascularized composite and reconstructive transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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    Testa, G., Koon, E. C., Johannesson, L., McKenna, G. J., Anthony, T., Klintmalm, G. B., Gunby, R. T., Warren, A. M., Putman, J. M., dePrisco, G., Mitchell, J. M., Wallis, K., & Olausson, M. (2017). Living Donor Uterus Transplantation: A Single Center's Observations and Lessons Learned From Early Setbacks to Technical Success. American Journal of Transplantation, 17(11), 2901-2910. https://doi.org/10.1111/ajt.14326