Localized proton spectroscopy without water suppression: Removal of gradient induced frequency modulations by modulus signal selection

Haçène Serrai, David B. Clayton, Lotfi Senhadji, Chun Zuo, Robert E. Lenkinski

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Most Magnetic Resonance Spectroscopy (MRS) localization methods can generate gradient vibrations at acoustic frequencies and/or magnetic field oscillation, which can cause a time-varying magnetic field superimposed onto the static one. This effect can produce frequency modulations of the spectral resonances. When localized MRS data are acquired without water suppression, the associated frequency modulations are manifested as a manifold of spurious peaks, called sidebands, which occur symmetrically around the water resonance. These sidebands can be larger than the small metabolite resonances and can present a problem for the quantitation of the spectra, especially at short echo times. Furthermore, the resonance lineshapes may be distorted if any low frequency modulations are present. A simple solution is presented which consists of selecting the modulus of the acquired Free Induction Decay (FID) signal. Since the frequency modulations affect only the phase of the FID signal, the obtained real spectrum of the modulus is free from the spurious peaks where quantitative results may be directly obtained. Using this method, the distortions caused by the sidebands are removed. This is demonstrated by processing proton MRS spectra acquired without water suppression collected from a phantom containing metabolites at concentrations comparable to those in human brain and from a human subject using two different localization methods (PRESS and Chemical Shift Imaging PRESS-(CSI)). The results obtained illustrate the ability of this approach to remove the spurious peaks. The corrected spectra can then be fit accurately. This is confirmed by the results obtained from both the relative and the absolute metabolites concentrations in phantoms and in vivo.

Original languageEnglish (US)
Pages (from-to)53-59
Number of pages7
JournalJournal of Magnetic Resonance
Volume154
Issue number1
DOIs
StatePublished - 2002

Fingerprint

Frequency modulation
Magnetic resonance spectroscopy
frequency modulation
Protons
metabolites
Spectrum Analysis
magnetic resonance spectroscopy
Metabolites
sidebands
retarding
Spectroscopy
Magnetic Fields
gradients
protons
Water
Magnetic Resonance Spectroscopy
water
spectroscopy
induction
Magnetic fields

Keywords

  • Frequency modulations
  • Localized spectroscopy
  • Magnetic resonance spectroscopy
  • Water suppression

ASJC Scopus subject areas

  • Molecular Biology
  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Localized proton spectroscopy without water suppression : Removal of gradient induced frequency modulations by modulus signal selection. / Serrai, Haçène; Clayton, David B.; Senhadji, Lotfi; Zuo, Chun; Lenkinski, Robert E.

In: Journal of Magnetic Resonance, Vol. 154, No. 1, 2002, p. 53-59.

Research output: Contribution to journalArticle

Serrai, Haçène ; Clayton, David B. ; Senhadji, Lotfi ; Zuo, Chun ; Lenkinski, Robert E. / Localized proton spectroscopy without water suppression : Removal of gradient induced frequency modulations by modulus signal selection. In: Journal of Magnetic Resonance. 2002 ; Vol. 154, No. 1. pp. 53-59.
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