Location, Location, Location: Compartmentalization of NAD+ Synthesis and Functions in Mammalian Cells

Xiaolu A. Cambronne, W. Lee Kraus

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

The numerous biological roles of NAD+ are organized and coordinated via its compartmentalization within cells. The spatial and temporal partitioning of this intermediary metabolite is intrinsic to understanding the impact of NAD+ on cellular signaling and metabolism. We review evidence supporting the compartmentalization of steady-state NAD+ levels in cells, as well as how the modulation of NAD+ synthesis dynamically regulates signaling by controlling subcellular NAD+ concentrations. We further discuss potential benefits to the cell of compartmentalizing NAD+, and methods for measuring subcellular NAD+ levels.

Original languageEnglish (US)
Pages (from-to)858-873
Number of pages16
JournalTrends in biochemical sciences
Volume45
Issue number10
DOIs
StatePublished - Oct 2020

Keywords

  • CD38
  • nicotinamide mononucleotide adenylyltransferase (NMNAT)
  • nicotinamide phosphoribosyltransferase (NAMPT)
  • poly(ADP-ribose) polymerase (PARP)
  • sirtuin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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