Long non-coding RNAs and complex human diseases

Jing Li, Zhenyu Xuan, Changning Liu

Research output: Contribution to journalReview article

104 Scopus citations

Abstract

Long non-coding RNAs (lncRNAs) are a heterogeneous class of RNAs that are generally defined as non-protein-coding transcripts longer than 200 nucleotides. Recently, an increasing number of studies have shown that lncRNAs can be involved in various critical biological processes, such as chromatin remodeling, gene transcription, and protein transport and trafficking. Moreover, lncRNAs are dysregulated in a number of complex human diseases, including coronary artery diseases, autoimmune diseases, neurological disorders, and various cancers, which indicates their important roles in these diseases. Here, we reviewed the current understanding of lncRNAs, including their definition and subclassification, regulatory functions, and potential roles in different types of complex human diseases.

Original languageEnglish (US)
Pages (from-to)18790-18808
Number of pages19
JournalInternational journal of molecular sciences
Volume14
Issue number9
DOIs
StatePublished - Sep 12 2013

Keywords

  • Complex human disease
  • Long non-coding RNA
  • Non-coding RNA

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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