Long term outcomes following surgical resection of myxopapillary ependymomas

Carlos A. Bagley, Sean Wilson, Karl F. Kothbauer, Markus J. Bookland, Fred Epstein, George I. Jallo

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Myxopapillary ependymomas, a specific tumor variant of spinal cord ependymomas, occur most commonly in the lumbosacral region. During the study period, 1,013 patients underwent surgery for spinal cord tumors. Fifty-two of the patients had a myxopapillary ependymoma. Forty-eight of these patients underwent surgery at our institutions. There were four patients who came for consultations only. Fourteen pediatric patients were diagnosed with myxopapillary ependymoma. The overall average age at which a patient was diagnosed was 31.8 years. The average age a child was diagnosed was 12.6 years. The adult mean age was 38.7 years. The clinical presentation was of a slow, indolent course, with average symptom duration of 20.8 months. Overall, the pediatric patients had a much more aggressive clinical course with a much higher rate of local recurrence and dissemination of the tumor within the neural axis (64% versus 32%). The median time to disease recurrence was 88 months for the entire group. The overall survival after 11.5 years of follow-up was 94%. The optimal management of patients harboring myxopapillary ependymomas remains somewhat controversial. Excellent outcomes may be obtained, however, with the use of aggressive surgical techniques. No clear benefit for adjunctive chemotherapy, and radiation therapy was demonstrated.

Original languageEnglish (US)
Pages (from-to)321-334
Number of pages14
JournalNeurosurgical Review
Issue number3
StatePublished - Jul 2009


  • Ependymoma
  • Intradural
  • Myxopapillary ependymoma
  • Spine tumor

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


Dive into the research topics of 'Long term outcomes following surgical resection of myxopapillary ependymomas'. Together they form a unique fingerprint.

Cite this