Loss of heterozygosity in a gene coding for a thyroid hormone receptor in lung cancers

F. Leduc; H. Brauch; C. Hajj; A. Dobrovic; F. Kaye; A. Gazdar; J. W. Harbour; O. S. Pettengill; G. D. Sorenson; A. Van Den Berg; K. Kok; B. Campling; F. Paquin; W. E C Bradley; B. Zbar; J. Minna; C. Buys; J. Ayoub

Loss of heterozygosity in a gene coding for a thyroid hormone receptor in lung cancers

F. Leduc, H. Brauch, C. Hajj, A. Dobrovic, F. Kaye, A. Gazdar, J. W. Harbour, O. S. Pettengill, G. D. Sorenson, A. Van Den Berg, K. Kok, B. Campling, F. Paquin, W. E C Bradley, B. Zbar, J. Minna, C. Buys, J. Ayoub

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

The ERBAβ gene codes for a DNA-binding thyroid hormone receptor (THR) and maps to chromosome 3p21-p25, overlapping a 3p deletion characterizing small-cell lung carcinoma (SCLC). A DNA clone detecting an RFLP at the ERBAβ locus has been used to probe a large number of lung tumors. Virtually all SCLC had lost heterozygosity, showing that the 3p deletion in SCLC includes this gene. A substantial but smaller proportion of non-small-cell carcinomas had lost heterozygosity at ERBAβ. Among all non-small-cell tumors some had lost heterozygosity at the proximal locus DFN15S2 (band 3p21) but not at ERBAβ, whereas none were found where the reverse was true. Therefore, the locus which plays a role in non-small-cell tumorigenesis probably lies closer to DNF15S2 than to ERBAβ and is almost certainly not the latter.

Original language	English (US)
Pages (from-to)	282-287
Number of pages	6
Journal	American Journal of Human Genetics
Volume	44
Issue number	2
State	Published - 1989

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Cite this

Leduc, F., Brauch, H., Hajj, C., Dobrovic, A., Kaye, F., Gazdar, A., Harbour, J. W., Pettengill, O. S., Sorenson, G. D., Van Den Berg, A., Kok, K., Campling, B., Paquin, F., Bradley, W. E. C., Zbar, B., Minna, J., Buys, C., & Ayoub, J. (1989). Loss of heterozygosity in a gene coding for a thyroid hormone receptor in lung cancers. American Journal of Human Genetics, 44(2), 282-287.

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abstract = "The ERBAβ gene codes for a DNA-binding thyroid hormone receptor (THR) and maps to chromosome 3p21-p25, overlapping a 3p deletion characterizing small-cell lung carcinoma (SCLC). A DNA clone detecting an RFLP at the ERBAβ locus has been used to probe a large number of lung tumors. Virtually all SCLC had lost heterozygosity, showing that the 3p deletion in SCLC includes this gene. A substantial but smaller proportion of non-small-cell carcinomas had lost heterozygosity at ERBAβ. Among all non-small-cell tumors some had lost heterozygosity at the proximal locus DFN15S2 (band 3p21) but not at ERBAβ, whereas none were found where the reverse was true. Therefore, the locus which plays a role in non-small-cell tumorigenesis probably lies closer to DNF15S2 than to ERBAβ and is almost certainly not the latter.",

author = "F. Leduc and H. Brauch and C. Hajj and A. Dobrovic and F. Kaye and A. Gazdar and Harbour, {J. W.} and Pettengill, {O. S.} and Sorenson, {G. D.} and {Van Den Berg}, A. and K. Kok and B. Campling and F. Paquin and Bradley, {W. E C} and B. Zbar and J. Minna and C. Buys and J. Ayoub",

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AU - Leduc, F.

AU - Brauch, H.

AU - Hajj, C.

AU - Dobrovic, A.

AU - Kaye, F.

AU - Gazdar, A.

AU - Harbour, J. W.

AU - Pettengill, O. S.

AU - Sorenson, G. D.

AU - Van Den Berg, A.

AU - Kok, K.

AU - Campling, B.

AU - Paquin, F.

AU - Bradley, W. E C

AU - Zbar, B.

AU - Minna, J.

AU - Buys, C.

AU - Ayoub, J.

PY - 1989

Y1 - 1989

N2 - The ERBAβ gene codes for a DNA-binding thyroid hormone receptor (THR) and maps to chromosome 3p21-p25, overlapping a 3p deletion characterizing small-cell lung carcinoma (SCLC). A DNA clone detecting an RFLP at the ERBAβ locus has been used to probe a large number of lung tumors. Virtually all SCLC had lost heterozygosity, showing that the 3p deletion in SCLC includes this gene. A substantial but smaller proportion of non-small-cell carcinomas had lost heterozygosity at ERBAβ. Among all non-small-cell tumors some had lost heterozygosity at the proximal locus DFN15S2 (band 3p21) but not at ERBAβ, whereas none were found where the reverse was true. Therefore, the locus which plays a role in non-small-cell tumorigenesis probably lies closer to DNF15S2 than to ERBAβ and is almost certainly not the latter.

AB - The ERBAβ gene codes for a DNA-binding thyroid hormone receptor (THR) and maps to chromosome 3p21-p25, overlapping a 3p deletion characterizing small-cell lung carcinoma (SCLC). A DNA clone detecting an RFLP at the ERBAβ locus has been used to probe a large number of lung tumors. Virtually all SCLC had lost heterozygosity, showing that the 3p deletion in SCLC includes this gene. A substantial but smaller proportion of non-small-cell carcinomas had lost heterozygosity at ERBAβ. Among all non-small-cell tumors some had lost heterozygosity at the proximal locus DFN15S2 (band 3p21) but not at ERBAβ, whereas none were found where the reverse was true. Therefore, the locus which plays a role in non-small-cell tumorigenesis probably lies closer to DNF15S2 than to ERBAβ and is almost certainly not the latter.

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AN - SCOPUS:0024529776

SN - 0002-9297

VL - 44

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JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

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Loss of heterozygosity in a gene coding for a thyroid hormone receptor in lung cancers

Abstract

ASJC Scopus subject areas

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