Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure

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9 Citations (Scopus)

Abstract

Peripheral neural sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechanisms underlying vagal sensing itself. Recently, we identified an enrichment of liver X receptor alpha and beta (LXRα/β) in the nodose ganglia of the vagus nerve. In this study, we show mice lacking LXRα/β in peripheral sensory neurons have increased energy expenditure and weight loss when fed a Western diet (WD). Our findings suggest that the ability to metabolize and sense cholesterol and/or fatty acids in peripheral neurons is an important requirement for physiological adaptations to WDs.

Original languageEnglish (US)
Article numbere06667
JournaleLife
Volume4
Issue numberJUNE
DOIs
StatePublished - Jun 15 2015

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Sensory Receptor Cells
Liver
Energy Metabolism
Neurons
Nodose Ganglion
Physiological Adaptation
Vagus Nerve
Nutrition
Weight Loss
Fatty Acids
Cholesterol
Liver X Receptors
Western Diet

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)
  • Neuroscience(all)

Cite this

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title = "Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure",
abstract = "Peripheral neural sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechanisms underlying vagal sensing itself. Recently, we identified an enrichment of liver X receptor alpha and beta (LXRα/β) in the nodose ganglia of the vagus nerve. In this study, we show mice lacking LXRα/β in peripheral sensory neurons have increased energy expenditure and weight loss when fed a Western diet (WD). Our findings suggest that the ability to metabolize and sense cholesterol and/or fatty acids in peripheral neurons is an important requirement for physiological adaptations to WDs.",
author = "Virginie Mansuy-Aubert and Laurent Gautron and Syann Lee and Bookout, {Angie L.} and Kusminski, {Christine M.} and Kai Sun and Yuan Zhang and Scherer, {Philipp E.} and Mangelsdorf, {David J.} and Elmquist, {Joel K.}",
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T1 - Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure

AU - Mansuy-Aubert, Virginie

AU - Gautron, Laurent

AU - Lee, Syann

AU - Bookout, Angie L.

AU - Kusminski, Christine M.

AU - Sun, Kai

AU - Zhang, Yuan

AU - Scherer, Philipp E.

AU - Mangelsdorf, David J.

AU - Elmquist, Joel K.

PY - 2015/6/15

Y1 - 2015/6/15

N2 - Peripheral neural sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechanisms underlying vagal sensing itself. Recently, we identified an enrichment of liver X receptor alpha and beta (LXRα/β) in the nodose ganglia of the vagus nerve. In this study, we show mice lacking LXRα/β in peripheral sensory neurons have increased energy expenditure and weight loss when fed a Western diet (WD). Our findings suggest that the ability to metabolize and sense cholesterol and/or fatty acids in peripheral neurons is an important requirement for physiological adaptations to WDs.

AB - Peripheral neural sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechanisms underlying vagal sensing itself. Recently, we identified an enrichment of liver X receptor alpha and beta (LXRα/β) in the nodose ganglia of the vagus nerve. In this study, we show mice lacking LXRα/β in peripheral sensory neurons have increased energy expenditure and weight loss when fed a Western diet (WD). Our findings suggest that the ability to metabolize and sense cholesterol and/or fatty acids in peripheral neurons is an important requirement for physiological adaptations to WDs.

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