TY - JOUR
T1 - Lovastatin therapy in nephrotic hyperlipidemia
T2 - Effects on lipoprotein metabolism
AU - Vega, Gloria L
AU - Grundy, Scott M
N1 - Funding Information:
The authors express appreciation to Biman Pramanik, Carolyn Cray, Ruth Jiles-Jackson, Deidra Lewis, Cinthia Stenoien, Rosemary Abate and Marjorie Whelan for technical assistance. We thank Dr. William F. Beltz for consultation and assistance in kinetic modeling. The partici-pation of the nursing and dietetic staffs of the metabolic unit of the Veterans Administration Medical Center is gratefully acknowledged. This research was supported by the Veterans Administration, the National Institutes of Health (grant HL-29252), the Southwestern Medical Foundation, and the Moss Heart Foundation.
PY - 1988
Y1 - 1988
N2 - The nephrotic syndrome is characterized by proteinuria, hypoalbuminemia, and hypercholesterolemia. Hypertriglyceridemia often is present as well. In this study, the kinetics of plasma lipoproteins were investigated in four patients with nephrotic hyperlipidemia, and repeat studies were carried out in three of these patients during therapy with lovastatin. Before lovastatin therapy, the patients had an extremely delayed catabolism of very low density lipoproteins (VLDL) without evidence of overproduction of lipoproteins in this fraction. Three of four patients had elevated levels of low density lipoprotein (LDL) that were due mainly to increased production rates for LDL. In the three patients treated with lovastatin, the drug therapy lowered plasma concentrations of total cholesterol, triglycerides, VLDL-cholesterol, and LDL-cholesterol, and raised high density lipoprotein (HDL)-cholesterol. Lovastatin therapy decreased VLDL-triglycerides primarily by enhancing their catabolism, and lowered LDL-cholesterol levels mainly by reducing input rates for LDL. Overall, lovastatin appears to be an effective drug for the treatment of hyperlipidemia in the nephrotic syndrome.
AB - The nephrotic syndrome is characterized by proteinuria, hypoalbuminemia, and hypercholesterolemia. Hypertriglyceridemia often is present as well. In this study, the kinetics of plasma lipoproteins were investigated in four patients with nephrotic hyperlipidemia, and repeat studies were carried out in three of these patients during therapy with lovastatin. Before lovastatin therapy, the patients had an extremely delayed catabolism of very low density lipoproteins (VLDL) without evidence of overproduction of lipoproteins in this fraction. Three of four patients had elevated levels of low density lipoprotein (LDL) that were due mainly to increased production rates for LDL. In the three patients treated with lovastatin, the drug therapy lowered plasma concentrations of total cholesterol, triglycerides, VLDL-cholesterol, and LDL-cholesterol, and raised high density lipoprotein (HDL)-cholesterol. Lovastatin therapy decreased VLDL-triglycerides primarily by enhancing their catabolism, and lowered LDL-cholesterol levels mainly by reducing input rates for LDL. Overall, lovastatin appears to be an effective drug for the treatment of hyperlipidemia in the nephrotic syndrome.
UR - http://www.scopus.com/inward/record.url?scp=0023948210&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023948210&partnerID=8YFLogxK
U2 - 10.1038/ki.1988.125
DO - 10.1038/ki.1988.125
M3 - Article
C2 - 3165483
AN - SCOPUS:0023948210
SN - 0085-2538
VL - 33
SP - 1160
EP - 1168
JO - Kidney international
JF - Kidney international
IS - 6
ER -