Lovastatin therapy in receptor-negative homozygous familial hypercholesterolemia: Lack of effect on low-density lipoprotein concentrations or turnover

Ricardo Uauy, Gloria L Vega, Scott M Grundy, David M. Bilheimer

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67 Scopus citations


To determine whether at least part of the fall in low density lipoprotein (LDL) levels during lovastatin therapy might be the result of a reduced secretion of lipoproteins by the liver, three children 6 to 9 years of age with receptor-negative homozygous familial hypercholesterolemia underwent treatment with lovastatin. These patients have no capacity to synthesize LDL receptors. During lovastatin therapy, at a dose of 2 mg/kg/day, there was no decrease in LDL-cholesterol levels, nor was the turnover rate of LDL affected by the drug. The only significant change was a 74% drop in very low-density lipoprotein during treatment. We conclude that lovastatin is not effective in treatment of receptor-negative homozygous familial hypercholesterolemia. The most likely mechanism of action for this drug is to increase LDL receptor activity.

Original languageEnglish (US)
Pages (from-to)387-392
Number of pages6
JournalThe Journal of Pediatrics
Issue number2
Publication statusPublished - 1988


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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