Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes

Chikako Nakajima; Akos Kulik; Michael Frotscher; Joachim Herz; Michael Schäfer; Hans H. Bock; Petra May

doi:10.1074/jbc.M112.444364

Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes

Chikako Nakajima, Akos Kulik, Michael Frotscher, Joachim Herz, Michael Schäfer, Hans H. Bock, Petra May

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Background: Neuronally LRP1-deficient mice show severe neurological signs and symptoms. Results: Neuronal LRP1 is cleaved by -secretase and regulates NMDA-dependent signaling and protein turnover. Conclusion: LRP1 modulates postsynaptic protein complexes and thus has the potential to influence synaptic transmission. Significance: This might explain why neuronal LRP1 is essential in vivo and shed light on its genetic association with neurodegenerative disease (i.e. Alzheimer disease).

Original language	English (US)
Pages (from-to)	21909-21923
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	288
Issue number	30
DOIs	https://doi.org/10.1074/jbc.M112.444364
State	Published - Jul 26 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Nakajima, C., Kulik, A., Frotscher, M., Herz, J., Schäfer, M., Bock, H. H., & May, P. (2013). Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes. Journal of Biological Chemistry, 288(30), 21909-21923. https://doi.org/10.1074/jbc.M112.444364

Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes. / Nakajima, Chikako; Kulik, Akos; Frotscher, Michael et al.
In: Journal of Biological Chemistry, Vol. 288, No. 30, 26.07.2013, p. 21909-21923.

Research output: Contribution to journal › Article › peer-review

Nakajima, C, Kulik, A, Frotscher, M, Herz, J, Schäfer, M, Bock, HH & May, P 2013, 'Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes', Journal of Biological Chemistry, vol. 288, no. 30, pp. 21909-21923. https://doi.org/10.1074/jbc.M112.444364

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Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes

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