Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes

Chikako Nakajima, Akos Kulik, Michael Frotscher, Joachim Herz, Michael Schäfer, Hans H. Bock, Petra May

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Background: Neuronally LRP1-deficient mice show severe neurological signs and symptoms. Results: Neuronal LRP1 is cleaved by -secretase and regulates NMDA-dependent signaling and protein turnover. Conclusion: LRP1 modulates postsynaptic protein complexes and thus has the potential to influence synaptic transmission. Significance: This might explain why neuronal LRP1 is essential in vivo and shed light on its genetic association with neurodegenerative disease (i.e. Alzheimer disease).

Original languageEnglish (US)
Pages (from-to)21909-21923
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number30
DOIs
StatePublished - Jul 26 2013

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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