TY - JOUR
T1 - Low-dose fentanyl reduces pain perception, muscle sympathetic nerve activity responses, and blood pressure responses during the cold pressor test
AU - Watso, Joseph C.
AU - Huang, Mu
AU - Belval, Luke N.
AU - Cimino, Frank A.
AU - Jarrard, Caitlin P.
AU - Hendrix, Joseph M.
AU - Hinojosa-Laborde, Carmen
AU - Crandall, Craig G.
N1 - Funding Information:
This research was supported by the Department of Defense— United States Army Grant W81XWH1820012 (to C. G. Crandall), National Institutes of Health (NIH) Grant F32HL154559 (to J. C. Watso), NIH Grant F32HL154565 (to L. N. Belval), and by the American Physiological Society Postdoctoral Fellowship (to J. C. Watso).
Funding Information:
This research was supported by the Department of Defense?United States Army Grant W81XWH1820012 (to C. G. Crandall), National Institutes of Health (NIH) Grant F32HL154559 (to J. C. Watso), NIH Grant F32HL154565 (to L. N. Belval), and by the American Physiological Society Postdoctoral Fellowship (to J. C. Watso).
Publisher Copyright:
© 2022 American Physiological Society. All rights reserved.
PY - 2022/1
Y1 - 2022/1
N2 - Our knowledge about how low-dose (analgesic) fentanyl affects autonomic cardiovascular regulation is primarily limited to animal experiments. Notably, it is unknown if low-dose fentanyl influences human autonomic cardiovascular responses during painful stimuli in humans. Therefore, we tested the hypothesis that low-dose fentanyl reduces perceived pain and subsequent sympathetic and cardiovascular responses in humans during an experimental noxious stimulus. Twenty-three adults (10 females/13 males; 27 ± 7 yr; 26 ± 3 kg·m-2, means ± SD) completed this randomized, crossover, placebo-controlled trial during two laboratory visits. During each visit, participants completed a cold pressor test (CPT; hand in ~0.4C ice bath for 2 min) before and 5 min after drug/placebo administration (75 μg fentanyl or saline). We compared pain perception (100-mm visual analog scale), muscle sympathetic nerve activity (MSNA; microneurography, 11 paired recordings), and beat-to-beat blood pressure (BP; photoplethysmography) between trials (at both pre- and postdrug/placebo timepoints) using paired, two-tailed t tests. Before drug/placebo administration, perceived pain (P = 0.8287), DMSNA burst frequency (P = 0.7587), and Dmean BP (P = 0.8649) during the CPT were not different between trials. After the drug/placebo administration, fentanyl attenuated perceived pain (36 vs. 66 mm, P < 0.0001), DMSNA burst frequency (9 vs. 17 bursts/min, P = 0.0054), and Dmean BP (7 vs. 13 mmHg, P = 0.0174) during the CPT compared with placebo. Fentanyl-induced reductions in pain perception and Dmean BP were moderately related (r = 0.40, P = 0.0641). These data provide valuable information regarding how low-dose fentanyl reduces autonomic cardiovascular responses during an experimental painful stimulus.
AB - Our knowledge about how low-dose (analgesic) fentanyl affects autonomic cardiovascular regulation is primarily limited to animal experiments. Notably, it is unknown if low-dose fentanyl influences human autonomic cardiovascular responses during painful stimuli in humans. Therefore, we tested the hypothesis that low-dose fentanyl reduces perceived pain and subsequent sympathetic and cardiovascular responses in humans during an experimental noxious stimulus. Twenty-three adults (10 females/13 males; 27 ± 7 yr; 26 ± 3 kg·m-2, means ± SD) completed this randomized, crossover, placebo-controlled trial during two laboratory visits. During each visit, participants completed a cold pressor test (CPT; hand in ~0.4C ice bath for 2 min) before and 5 min after drug/placebo administration (75 μg fentanyl or saline). We compared pain perception (100-mm visual analog scale), muscle sympathetic nerve activity (MSNA; microneurography, 11 paired recordings), and beat-to-beat blood pressure (BP; photoplethysmography) between trials (at both pre- and postdrug/placebo timepoints) using paired, two-tailed t tests. Before drug/placebo administration, perceived pain (P = 0.8287), DMSNA burst frequency (P = 0.7587), and Dmean BP (P = 0.8649) during the CPT were not different between trials. After the drug/placebo administration, fentanyl attenuated perceived pain (36 vs. 66 mm, P < 0.0001), DMSNA burst frequency (9 vs. 17 bursts/min, P = 0.0054), and Dmean BP (7 vs. 13 mmHg, P = 0.0174) during the CPT compared with placebo. Fentanyl-induced reductions in pain perception and Dmean BP were moderately related (r = 0.40, P = 0.0641). These data provide valuable information regarding how low-dose fentanyl reduces autonomic cardiovascular responses during an experimental painful stimulus.
KW - Algometry
KW - Cerebral tissue oxygenation
KW - Opioids
KW - Respiration
KW - Sympathoexcitatory
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U2 - 10.1152/AJPREGU.00218.2021
DO - 10.1152/AJPREGU.00218.2021
M3 - Article
C2 - 34851729
AN - SCOPUS:85123228295
VL - 322
SP - 64
EP - 76
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
SN - 0363-6135
IS - 1
ER -