Low-grade Bone Lesions in Survivors of Childhood Medulloblastoma/Primitive Neuroectodermal Tumor

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Abstract

Objectives and Rationale: Medulloblastoma/primitive neuroectodermal tumor (MB/PNET) is the most common malignant tumor of the central nervous system (CNS) in children. MB/PNET survivors are at an increased risk for developing second malignancies. Little has been reported on development of low-grade lesions of the calvarium in the radiation field in MB/PNET survivors. The purpose of this study was to assess the frequency of the low-grade bone lesion development in the radiotherapy field in pediatric MB/PNET survivors and describe the imaging characteristics of these lesions. Materials and Methods: Institutional review board approval was obtained for this retrospective review which was compliant with Health Insurance Portability and Accountability Act. Forty-one MB/PNET patients (29 male) who survived for at least 2 years after initiation of radiation therapy were included. The medical records were reviewed. The most recent available brain magnetic resonance imaging studies were evaluated. Results: Three patients (7.3%) developed low-grade calvarial lesions and underwent resection and/or biopsy of the lesions. There were one Langerhans cell histiocytosis, one benign spindle cell lesion with myxoid change, and one fibrous dysplasia. Conclusion: Development of low-grade bone lesions of calvarium is not very rare in pediatric PNET/MB survivors. Bones in the radiation therapy field need to be carefully examined for assessment of secondary lesions.

Original languageEnglish (US)
Pages (from-to)35-39
Number of pages5
JournalAcademic Radiology
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 2012

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Keywords

  • Children
  • Low-grade bone lesion
  • Medulloblastoma
  • Primitive neuroectodermal tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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