Low-quality housing is associated with increased risk of malaria infection: A national population-based study from the low transmission setting of Swaziland

Nomcebo Dlamini, Michelle S. Hsiang, Nyasatu Ntshalintshali, Deepa Pindolia, Regan Allen, Nomcebo Nhlabathi, Joseph Novotny, Mi Suk Kang Dufour, Alemayehu Midekisa, Roly Gosling, Arnaud LeMenach, Justin Cohen, Grant Dorsey, Bryan Greenhouse, Simon Kunene

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background. Low-quality housing may confer risk of malaria infection, but evidence in low transmission settings is limited. Methods. To examine the relationship between individual level housing quality and locally acquired infection in children and adults, a population-based cross-sectional analysis was performed using existing surveillance data from the low transmission setting of Swaziland. From 2012 to 2015, cases were identified through standard diagnostics in health facilities and by loop-mediated isothermal amplification in active surveillance, with uninfected subjects being household members and neighbors. Housing was visually assessed in a home visit and then classified as low, high, or medium quality, based on housing components being traditional, modern, or both, respectively. Results. Overall, 11 426 individuals were included in the study: 10 960 uninfected and 466 infected (301 symptomatic and 165 asymptomatic). Six percent resided in low-quality houses, 26% in medium-quality houses, and 68% in high-quality houses. In adjusted models, low- and medium-quality construction was associated with increased risk of malaria compared with high-quality construction (adjusted odds ratio [AOR], 2.11 and 95% confidence interval [CI], 1.26-3.53 for low vs high; AOR, 1.56 and 95% CI, 1.15-2.11 for medium vs high). The relationship was independent of vector control, which also conferred a protective effect (AOR, 0.67; 95% CI, .50-.90) for sleeping under an insecticide-treated bed net or a sprayed structure compared with neither. Conclusions. Our study adds to the limited literature on housing quality and malaria risk from low transmission settings. Housing improvements may offer an attractive and sustainable additional strategy to support countries in malaria elimination.

Original languageEnglish (US)
Article numberofx071
JournalOpen Forum Infectious Diseases
Volume4
Issue number2
DOIs
StatePublished - Mar 1 2017

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Swaziland
Malaria
Infection
Population
Odds Ratio
Confidence Intervals
Insecticide-Treated Bednets
House Calls
Health Facilities
Cross-Sectional Studies

Keywords

  • Housing
  • Low transmission
  • Malaria elimination
  • Swaziland
  • Vector control

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology

Cite this

Low-quality housing is associated with increased risk of malaria infection : A national population-based study from the low transmission setting of Swaziland. / Dlamini, Nomcebo; Hsiang, Michelle S.; Ntshalintshali, Nyasatu; Pindolia, Deepa; Allen, Regan; Nhlabathi, Nomcebo; Novotny, Joseph; Dufour, Mi Suk Kang; Midekisa, Alemayehu; Gosling, Roly; LeMenach, Arnaud; Cohen, Justin; Dorsey, Grant; Greenhouse, Bryan; Kunene, Simon.

In: Open Forum Infectious Diseases, Vol. 4, No. 2, ofx071, 01.03.2017.

Research output: Contribution to journalArticle

Dlamini, N, Hsiang, MS, Ntshalintshali, N, Pindolia, D, Allen, R, Nhlabathi, N, Novotny, J, Dufour, MSK, Midekisa, A, Gosling, R, LeMenach, A, Cohen, J, Dorsey, G, Greenhouse, B & Kunene, S 2017, 'Low-quality housing is associated with increased risk of malaria infection: A national population-based study from the low transmission setting of Swaziland', Open Forum Infectious Diseases, vol. 4, no. 2, ofx071. https://doi.org/10.1093/ofid/ofx071
Dlamini, Nomcebo ; Hsiang, Michelle S. ; Ntshalintshali, Nyasatu ; Pindolia, Deepa ; Allen, Regan ; Nhlabathi, Nomcebo ; Novotny, Joseph ; Dufour, Mi Suk Kang ; Midekisa, Alemayehu ; Gosling, Roly ; LeMenach, Arnaud ; Cohen, Justin ; Dorsey, Grant ; Greenhouse, Bryan ; Kunene, Simon. / Low-quality housing is associated with increased risk of malaria infection : A national population-based study from the low transmission setting of Swaziland. In: Open Forum Infectious Diseases. 2017 ; Vol. 4, No. 2.
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abstract = "Background. Low-quality housing may confer risk of malaria infection, but evidence in low transmission settings is limited. Methods. To examine the relationship between individual level housing quality and locally acquired infection in children and adults, a population-based cross-sectional analysis was performed using existing surveillance data from the low transmission setting of Swaziland. From 2012 to 2015, cases were identified through standard diagnostics in health facilities and by loop-mediated isothermal amplification in active surveillance, with uninfected subjects being household members and neighbors. Housing was visually assessed in a home visit and then classified as low, high, or medium quality, based on housing components being traditional, modern, or both, respectively. Results. Overall, 11 426 individuals were included in the study: 10 960 uninfected and 466 infected (301 symptomatic and 165 asymptomatic). Six percent resided in low-quality houses, 26{\%} in medium-quality houses, and 68{\%} in high-quality houses. In adjusted models, low- and medium-quality construction was associated with increased risk of malaria compared with high-quality construction (adjusted odds ratio [AOR], 2.11 and 95{\%} confidence interval [CI], 1.26-3.53 for low vs high; AOR, 1.56 and 95{\%} CI, 1.15-2.11 for medium vs high). The relationship was independent of vector control, which also conferred a protective effect (AOR, 0.67; 95{\%} CI, .50-.90) for sleeping under an insecticide-treated bed net or a sprayed structure compared with neither. Conclusions. Our study adds to the limited literature on housing quality and malaria risk from low transmission settings. Housing improvements may offer an attractive and sustainable additional strategy to support countries in malaria elimination.",
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AU - Ntshalintshali, Nyasatu

AU - Pindolia, Deepa

AU - Allen, Regan

AU - Nhlabathi, Nomcebo

AU - Novotny, Joseph

AU - Dufour, Mi Suk Kang

AU - Midekisa, Alemayehu

AU - Gosling, Roly

AU - LeMenach, Arnaud

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AB - Background. Low-quality housing may confer risk of malaria infection, but evidence in low transmission settings is limited. Methods. To examine the relationship between individual level housing quality and locally acquired infection in children and adults, a population-based cross-sectional analysis was performed using existing surveillance data from the low transmission setting of Swaziland. From 2012 to 2015, cases were identified through standard diagnostics in health facilities and by loop-mediated isothermal amplification in active surveillance, with uninfected subjects being household members and neighbors. Housing was visually assessed in a home visit and then classified as low, high, or medium quality, based on housing components being traditional, modern, or both, respectively. Results. Overall, 11 426 individuals were included in the study: 10 960 uninfected and 466 infected (301 symptomatic and 165 asymptomatic). Six percent resided in low-quality houses, 26% in medium-quality houses, and 68% in high-quality houses. In adjusted models, low- and medium-quality construction was associated with increased risk of malaria compared with high-quality construction (adjusted odds ratio [AOR], 2.11 and 95% confidence interval [CI], 1.26-3.53 for low vs high; AOR, 1.56 and 95% CI, 1.15-2.11 for medium vs high). The relationship was independent of vector control, which also conferred a protective effect (AOR, 0.67; 95% CI, .50-.90) for sleeping under an insecticide-treated bed net or a sprayed structure compared with neither. Conclusions. Our study adds to the limited literature on housing quality and malaria risk from low transmission settings. Housing improvements may offer an attractive and sustainable additional strategy to support countries in malaria elimination.

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KW - Malaria elimination

KW - Swaziland

KW - Vector control

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