Low sensitivity of skin biopsy in diagnosing small fiber neuropathy in Chinese Americans

Peter Jin, Ling Cheng, Ming Chen, Lan Zhou

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: To compare skin biopsy sensitivity for diagnosing small fiber sensory neuropathy in Chinese American and non-Chinese American patients. Methods: We screened our skin biopsy database and performed chart review to identify Chinese and non- Chinese American patients with a high clinical suspicion for a distal small fiber sensory neuropathy, and compared the skin biopsy sensitivity. Results: Twenty-three Chinese American and 32 non- Chinese American patients with the presence of distal small fiber sensory symptoms and signs were studied. Intraepidermal nerve fiber density (IENFD) (fibers/mm) at the distal leg was higher (7.1 ± 3.9), and the diagnostic sensitivity using the worldwide normative reference values of IENFD at the distal leg was lower (26.1%) in the Chinese American group than in the non-Chinese American group (5.1 ± 3.0, P < 0.05; 62.5%, P < 0.05). Conclusions: There may be ethnic differences in IENFD at the distal leg, and a different set of IENFD normative values may be developed for ethnic Chinese to improve the skin biopsy sensitivity.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalJournal of Clinical Neuromuscular Disease
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Asian Americans
Nerve Fibers
Biopsy
Skin
Leg
Signs and Symptoms
Reference Values
Small Fiber Neuropathy
Databases

Keywords

  • Ethnic differences
  • Intraepidermal nerve fiber density
  • Normative values
  • Skin biopsy
  • Small fiber sensory neuropathy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Low sensitivity of skin biopsy in diagnosing small fiber neuropathy in Chinese Americans. / Jin, Peter; Cheng, Ling; Chen, Ming; Zhou, Lan.

In: Journal of Clinical Neuromuscular Disease, Vol. 20, No. 1, 01.01.2018, p. 1-6.

Research output: Contribution to journalArticle

@article{f3222d669043422984a9105bc98be5d3,
title = "Low sensitivity of skin biopsy in diagnosing small fiber neuropathy in Chinese Americans",
abstract = "Objectives: To compare skin biopsy sensitivity for diagnosing small fiber sensory neuropathy in Chinese American and non-Chinese American patients. Methods: We screened our skin biopsy database and performed chart review to identify Chinese and non- Chinese American patients with a high clinical suspicion for a distal small fiber sensory neuropathy, and compared the skin biopsy sensitivity. Results: Twenty-three Chinese American and 32 non- Chinese American patients with the presence of distal small fiber sensory symptoms and signs were studied. Intraepidermal nerve fiber density (IENFD) (fibers/mm) at the distal leg was higher (7.1 ± 3.9), and the diagnostic sensitivity using the worldwide normative reference values of IENFD at the distal leg was lower (26.1{\%}) in the Chinese American group than in the non-Chinese American group (5.1 ± 3.0, P < 0.05; 62.5{\%}, P < 0.05). Conclusions: There may be ethnic differences in IENFD at the distal leg, and a different set of IENFD normative values may be developed for ethnic Chinese to improve the skin biopsy sensitivity.",
keywords = "Ethnic differences, Intraepidermal nerve fiber density, Normative values, Skin biopsy, Small fiber sensory neuropathy",
author = "Peter Jin and Ling Cheng and Ming Chen and Lan Zhou",
year = "2018",
month = "1",
day = "1",
doi = "10.1097/cnd.0000000000000223",
language = "English (US)",
volume = "20",
pages = "1--6",
journal = "Journal of Clinical Neuromuscular Disease",
issn = "1522-0443",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Low sensitivity of skin biopsy in diagnosing small fiber neuropathy in Chinese Americans

AU - Jin, Peter

AU - Cheng, Ling

AU - Chen, Ming

AU - Zhou, Lan

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objectives: To compare skin biopsy sensitivity for diagnosing small fiber sensory neuropathy in Chinese American and non-Chinese American patients. Methods: We screened our skin biopsy database and performed chart review to identify Chinese and non- Chinese American patients with a high clinical suspicion for a distal small fiber sensory neuropathy, and compared the skin biopsy sensitivity. Results: Twenty-three Chinese American and 32 non- Chinese American patients with the presence of distal small fiber sensory symptoms and signs were studied. Intraepidermal nerve fiber density (IENFD) (fibers/mm) at the distal leg was higher (7.1 ± 3.9), and the diagnostic sensitivity using the worldwide normative reference values of IENFD at the distal leg was lower (26.1%) in the Chinese American group than in the non-Chinese American group (5.1 ± 3.0, P < 0.05; 62.5%, P < 0.05). Conclusions: There may be ethnic differences in IENFD at the distal leg, and a different set of IENFD normative values may be developed for ethnic Chinese to improve the skin biopsy sensitivity.

AB - Objectives: To compare skin biopsy sensitivity for diagnosing small fiber sensory neuropathy in Chinese American and non-Chinese American patients. Methods: We screened our skin biopsy database and performed chart review to identify Chinese and non- Chinese American patients with a high clinical suspicion for a distal small fiber sensory neuropathy, and compared the skin biopsy sensitivity. Results: Twenty-three Chinese American and 32 non- Chinese American patients with the presence of distal small fiber sensory symptoms and signs were studied. Intraepidermal nerve fiber density (IENFD) (fibers/mm) at the distal leg was higher (7.1 ± 3.9), and the diagnostic sensitivity using the worldwide normative reference values of IENFD at the distal leg was lower (26.1%) in the Chinese American group than in the non-Chinese American group (5.1 ± 3.0, P < 0.05; 62.5%, P < 0.05). Conclusions: There may be ethnic differences in IENFD at the distal leg, and a different set of IENFD normative values may be developed for ethnic Chinese to improve the skin biopsy sensitivity.

KW - Ethnic differences

KW - Intraepidermal nerve fiber density

KW - Normative values

KW - Skin biopsy

KW - Small fiber sensory neuropathy

UR - http://www.scopus.com/inward/record.url?scp=85056654441&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056654441&partnerID=8YFLogxK

U2 - 10.1097/cnd.0000000000000223

DO - 10.1097/cnd.0000000000000223

M3 - Article

VL - 20

SP - 1

EP - 6

JO - Journal of Clinical Neuromuscular Disease

JF - Journal of Clinical Neuromuscular Disease

SN - 1522-0443

IS - 1

ER -