TY - JOUR
T1 - Lower levels of circulating progenitor cells are associated with low physical function and performance in elderly men with impaired glucose tolerance
T2 - A pilot substudy from the va enhanced fitness trial
AU - Povsic, Thomas J.
AU - Sloane, Richard
AU - Zhou, Jiying
AU - Pieper, Carl F.
AU - Pearson, Megan P.
AU - Peterson, Eric D.
AU - Green, Jennifer B.
AU - Cohen, Harvey J.
AU - Morey, Miriam C.
N1 - Funding Information:
Funding This study was supported by the Duke Claude D. Pepper Older Americans Independence Center (OAIC) Research Career Development, Administrative, and Research Cores, National Institute on Aging Research Grant 5P30AG028716 (T.J.P., R.S., C.F.P., and M.C.M.). The Enhanced Fitness study was funded by a VA Health Services Research and Development grant IIR-06-252-3 (M.C.M.). Intervention materials have been developed with prior support from VA Rehabilitation Research Service grants (RRD-E2756R, RRD-E3386R), National Cancer Institute grant CA106919 and ongoing OAIC support. M.C.M. is supported by the Durham VA Geriatric Research Education and Clinical Center.
PY - 2013
Y1 - 2013
N2 - Background. Aging is marked by a decline in physical function. Although the biological underpinnings for this remain unclear, loss of regenerative capacity has been proposed as one cause of the loss of physical function that occurs over time. The quantity of circulating progenitor cells (CPCs) may be one reflection of regenerative capability. We sought to determine whether certain specific CPC subpopulations were associated with physical function. Methods. Baseline CPCs were measured in 129 randomized participants in the Enhanced Fitness clinical trial based on the cell surface markers CD34, CD133, CD146, and CD14 and aldehyde dehydrogenase (ALDH) activity. Physical function was assessed using usual and rapid gait speed, 6-minute walk distance, chair stand time, and balance time. Results. Low counts of early angiogenic CPCs identified as CD34+, CD34+CD133+, and ALDH-bright (ALDHbr) cells were associated with low usual gait speed (p < .005, p < .001, and p < .007), rapid gait speed (p < .001, p < .003, and p < .001), and 6-minute walking distance (all comparisons p < .001), and longer time required to complete five chair stands (p < .006, p < .002, and p < .004). CPC counts of mature endothelial or monocytic markers were not associated with physical function. Conclusions. The numbers of CD34+ and ALDHbr CPCs are significantly lower in patients with impaired physical function. Further studies are needed to determine the underlying causes for this association.
AB - Background. Aging is marked by a decline in physical function. Although the biological underpinnings for this remain unclear, loss of regenerative capacity has been proposed as one cause of the loss of physical function that occurs over time. The quantity of circulating progenitor cells (CPCs) may be one reflection of regenerative capability. We sought to determine whether certain specific CPC subpopulations were associated with physical function. Methods. Baseline CPCs were measured in 129 randomized participants in the Enhanced Fitness clinical trial based on the cell surface markers CD34, CD133, CD146, and CD14 and aldehyde dehydrogenase (ALDH) activity. Physical function was assessed using usual and rapid gait speed, 6-minute walk distance, chair stand time, and balance time. Results. Low counts of early angiogenic CPCs identified as CD34+, CD34+CD133+, and ALDH-bright (ALDHbr) cells were associated with low usual gait speed (p < .005, p < .001, and p < .007), rapid gait speed (p < .001, p < .003, and p < .001), and 6-minute walking distance (all comparisons p < .001), and longer time required to complete five chair stands (p < .006, p < .002, and p < .004). CPC counts of mature endothelial or monocytic markers were not associated with physical function. Conclusions. The numbers of CD34+ and ALDHbr CPCs are significantly lower in patients with impaired physical function. Further studies are needed to determine the underlying causes for this association.
KW - Aging
KW - Endothelial progenitor cells
KW - Physical function
KW - Physical performance
KW - Progenitor cells biology
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U2 - 10.1093/gerona/glt067
DO - 10.1093/gerona/glt067
M3 - Article
C2 - 23682163
AN - SCOPUS:84891617054
SN - 1079-5006
VL - 68
SP - 1559
EP - 1566
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 12 A
ER -