TY - JOUR
T1 - Lymphoid microenvironment in the gut for immunoglobulin A and inflammation
AU - Chin, Robert
AU - Wang, Jing
AU - Fu, Yang X.
PY - 2003/10
Y1 - 2003/10
N2 - Signaling through lymphotoxm β receptor (LTβR) initiates the unfolding of a host of developmental programs ranging from the organogenesis of lymph nodes and Peyer's patches (PPs) to the coordination of splenic microarchitecture. While investigating an alternative pathway to immunoglobulin A (IgA) production, it was uncovered that LTβR signaling in the lamina propria (LP) stroma orchestrates the coordinated expression of key chemokines and adhesion molecules, creation of a cytokine milieu, and stroma development that facilitates robust IgA production independent of secondary lymphoid structures. Simultaneously, this same infrastructure can be commandeered by autoreactive T cells to organize both the acute destruction of the intestinal mucosa and chronic intestinal inflammation via the ligands for LTβR. The ability to modulate LTβR signaling may alternatively permit the suppression of autoimmune responses and augmentation of gut defenses.
AB - Signaling through lymphotoxm β receptor (LTβR) initiates the unfolding of a host of developmental programs ranging from the organogenesis of lymph nodes and Peyer's patches (PPs) to the coordination of splenic microarchitecture. While investigating an alternative pathway to immunoglobulin A (IgA) production, it was uncovered that LTβR signaling in the lamina propria (LP) stroma orchestrates the coordinated expression of key chemokines and adhesion molecules, creation of a cytokine milieu, and stroma development that facilitates robust IgA production independent of secondary lymphoid structures. Simultaneously, this same infrastructure can be commandeered by autoreactive T cells to organize both the acute destruction of the intestinal mucosa and chronic intestinal inflammation via the ligands for LTβR. The ability to modulate LTβR signaling may alternatively permit the suppression of autoimmune responses and augmentation of gut defenses.
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U2 - 10.1034/j.1600-065X.2003.00066.x
DO - 10.1034/j.1600-065X.2003.00066.x
M3 - Review article
C2 - 12969319
AN - SCOPUS:0141455036
SN - 0105-2896
VL - 195
SP - 190
EP - 201
JO - Immunological Reviews
JF - Immunological Reviews
ER -