Lynch syndrome related endometrial cancer

Clinical significance beyond the endometrium

Yiying Wang, Yue Wang, Jie Li, Janiel Cragun, Kenneth Hatch, Setsuko K. Chambers, Wenxin Zheng

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Lynch syndrome (LS), an autosomal dominant inherited cancer susceptibility syndrome, also known as hereditary non-polyposis colon cancer (HNPCC), is caused by a germline mutation in one of several DNA mismatch repair (MMR) genes. LS is the most common presentation of hereditary colorectal cancer (CRC), accounting for about 2-5% of all CRC cases. More recently, it is found that a similar number of endometrial cancers is also due to one of the MMR gene mutations. There has been significant progress in LS-related CRC in terms of molecular pathogenesis, risks, genetic basis, and cancer prevention. In contrast, the advance about LS-related endometrial cancer (EC) is very much limited. In this commentary, we summarize the main clinicopathologic features of LS-related EC and propose universal screening for LS in individuals with endometrial cancer.

Original languageEnglish (US)
Article number22
JournalJournal of Hematology and Oncology
Volume6
Issue number1
DOIs
StatePublished - Mar 27 2013

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Hereditary Nonpolyposis Colorectal Neoplasms
Endometrial Neoplasms
Endometrium
Colorectal Neoplasms
DNA Mismatch Repair
Germ-Line Mutation
Colonic Neoplasms
Genes
Neoplasms
Mutation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research
  • Molecular Biology

Cite this

Lynch syndrome related endometrial cancer : Clinical significance beyond the endometrium. / Wang, Yiying; Wang, Yue; Li, Jie; Cragun, Janiel; Hatch, Kenneth; Chambers, Setsuko K.; Zheng, Wenxin.

In: Journal of Hematology and Oncology, Vol. 6, No. 1, 22, 27.03.2013.

Research output: Contribution to journalReview article

Wang, Yiying ; Wang, Yue ; Li, Jie ; Cragun, Janiel ; Hatch, Kenneth ; Chambers, Setsuko K. ; Zheng, Wenxin. / Lynch syndrome related endometrial cancer : Clinical significance beyond the endometrium. In: Journal of Hematology and Oncology. 2013 ; Vol. 6, No. 1.
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