Macrophage functions are regulated by the substratum of murine decidual stromal cells

Raymond W. Redline, Dianne B. McKay, Miguel A. Vazquez, Virginia E. Papaioannou, Christopher Y. Lu, Colleen M. Shea, Sherri R. Schmalzried

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Because of their paternal antigens, the fetus and placenta may be considered an allograft in the maternal host. Local properties of the maternal-fetal interface, the placenta and decidua basalis, are important in preventing maternal immunologic rejection of the fetoplacental allograft. However, the exact nature of these local properties remains a fundamental unsolved problem in immunology. We now report that three macrophage functions were inhibited by the substratum formed by monolayers of decidual stromal cells via a novel pathway. Solidphase inhibitors blocked macrophage adhesion, spreading, and lysis of tumor necrosis factor-α-resistant P815 mastocytoma tumor cells. Inhibition was not solely attributable to an inability of macrophages to adhere to decidual substratum because there were differences in macrophage functions on this surface versus polyhema where no adherence occurred. Because macrophages play a central role in cell-mediated immunity, including allograft rejection, inhibiting their function in the decidua basalis may help prevent maternal antifetal responses.

Original languageEnglish (US)
Pages (from-to)1951-1958
Number of pages8
JournalJournal of Clinical Investigation
Volume85
Issue number6
StatePublished - Jun 1990

Fingerprint

Stromal Cells
Macrophages
Mothers
Allografts
Decidua
Placenta
Mastocytoma
Allergy and Immunology
Cellular Immunity
Fetus
Tumor Necrosis Factor-alpha
Antigens
Neoplasms

Keywords

  • Allograft
  • Decidua basalis
  • Macrophages
  • Placenta
  • Rejection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Redline, R. W., McKay, D. B., Vazquez, M. A., Papaioannou, V. E., Lu, C. Y., Shea, C. M., & Schmalzried, S. R. (1990). Macrophage functions are regulated by the substratum of murine decidual stromal cells. Journal of Clinical Investigation, 85(6), 1951-1958.

Macrophage functions are regulated by the substratum of murine decidual stromal cells. / Redline, Raymond W.; McKay, Dianne B.; Vazquez, Miguel A.; Papaioannou, Virginia E.; Lu, Christopher Y.; Shea, Colleen M.; Schmalzried, Sherri R.

In: Journal of Clinical Investigation, Vol. 85, No. 6, 06.1990, p. 1951-1958.

Research output: Contribution to journalArticle

Redline, RW, McKay, DB, Vazquez, MA, Papaioannou, VE, Lu, CY, Shea, CM & Schmalzried, SR 1990, 'Macrophage functions are regulated by the substratum of murine decidual stromal cells', Journal of Clinical Investigation, vol. 85, no. 6, pp. 1951-1958.
Redline, Raymond W. ; McKay, Dianne B. ; Vazquez, Miguel A. ; Papaioannou, Virginia E. ; Lu, Christopher Y. ; Shea, Colleen M. ; Schmalzried, Sherri R. / Macrophage functions are regulated by the substratum of murine decidual stromal cells. In: Journal of Clinical Investigation. 1990 ; Vol. 85, No. 6. pp. 1951-1958.
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