Macrophage signaling pathways in pulmonary nontuberculous mycobacteria infections

Zohra Prasla, Roy L. Sutliff, Ruxana T. Sadikot

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The incidence and prevalence of nontuberculous mycobacteria (NTM) lung disease is rising worldwide and accounts for most clinical cases of NTM disease. NTM infections occur in both immunocompetent and immunocompromised hosts. Macrophages are the primary host cells that initiate an immune response to NTM. Defining the molecular events that govern the control of infection within macrophages is fundamental to understanding the pathogenesis of NTM disease. Here, we review key macrophage host signaling pathways that contribute to the host immune response to pulmonaryNTMinfections. In this review, we focus primarily on NTM that are known to cause lung disease, including Mycobacterium avium intracellulare, M. abscessus, and M. kansasii.

Original languageEnglish (US)
Pages (from-to)144-151
Number of pages8
JournalAmerican journal of respiratory cell and molecular biology
Volume63
Issue number2
DOIs
StatePublished - Aug 2020

Keywords

  • Autophagy
  • Inflammasome
  • Macrophage
  • Mycobacterium abscessus
  • Mycobacterium avium

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry
  • Cell Biology

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