Abstract
From 1962 through 1987, four children were diagnosed at our institution with primary germ cell malignancies of the extracranial head and neck regions. Ages of the children ranged from 2 to 44 months. Histologic findings included 2 yolk sac carcinoma (endodermal sinus tumor), 1 malignant teratoma with neuroblastoma (primitive neuroectodermal) components. Complete clinical and surgical staging was performed to rule out additional sites of disease. All patients initially underwent either biopsy or, when technically feasible, resection. Three patients received combination chemotherapy and two received irradiation. Three patients died of progressive disease. One patient who had yolk sac carcinoma of the temporomandibular region is alive and free of disease 40 months after therapy. Complete surgical resection is indicated for teratomatous tumors, if technically feasible. The malignant components of these tumors are sensitive to both chemotherapy and irradiation and combined therapy may be beneficial.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 732-735 |
| Number of pages | 4 |
| Journal | Laryngoscope |
| Volume | 99 |
| Issue number | 7 |
| State | Published - Jan 1 1989 |
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ASJC Scopus subject areas
- Otorhinolaryngology
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Malignant germ cell tumors of the head and neck in childhood. / Stephenson, Jeffery A.; Mayland, Diane M.; Kun, Larry E.; Etcubanas, Erlinda; Thompson, Elizabeth I.; Gross, Charles W.
In: Laryngoscope, Vol. 99, No. 7, 01.01.1989, p. 732-735.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Malignant germ cell tumors of the head and neck in childhood
AU - Stephenson, Jeffery A.
AU - Mayland, Diane M.
AU - Kun, Larry E.
AU - Etcubanas, Erlinda
AU - Thompson, Elizabeth I.
AU - Gross, Charles W.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - From 1962 through 1987, four children were diagnosed at our institution with primary germ cell malignancies of the extracranial head and neck regions. Ages of the children ranged from 2 to 44 months. Histologic findings included 2 yolk sac carcinoma (endodermal sinus tumor), 1 malignant teratoma with neuroblastoma (primitive neuroectodermal) components. Complete clinical and surgical staging was performed to rule out additional sites of disease. All patients initially underwent either biopsy or, when technically feasible, resection. Three patients received combination chemotherapy and two received irradiation. Three patients died of progressive disease. One patient who had yolk sac carcinoma of the temporomandibular region is alive and free of disease 40 months after therapy. Complete surgical resection is indicated for teratomatous tumors, if technically feasible. The malignant components of these tumors are sensitive to both chemotherapy and irradiation and combined therapy may be beneficial.
AB - From 1962 through 1987, four children were diagnosed at our institution with primary germ cell malignancies of the extracranial head and neck regions. Ages of the children ranged from 2 to 44 months. Histologic findings included 2 yolk sac carcinoma (endodermal sinus tumor), 1 malignant teratoma with neuroblastoma (primitive neuroectodermal) components. Complete clinical and surgical staging was performed to rule out additional sites of disease. All patients initially underwent either biopsy or, when technically feasible, resection. Three patients received combination chemotherapy and two received irradiation. Three patients died of progressive disease. One patient who had yolk sac carcinoma of the temporomandibular region is alive and free of disease 40 months after therapy. Complete surgical resection is indicated for teratomatous tumors, if technically feasible. The malignant components of these tumors are sensitive to both chemotherapy and irradiation and combined therapy may be beneficial.
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M3 - Article
C2 - 2545983
AN - SCOPUS:0024324334
VL - 99
SP - 732
EP - 735
JO - Laryngoscope
JF - Laryngoscope
SN - 0023-852X
IS - 7
ER -