Malignant germ cell tumors of the head and neck in childhood

Jeffery A. Stephenson, Diane M. Mayland, Larry E. Kun, Erlinda Etcubanas, Elizabeth I. Thompson, Charles W. Gross

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

From 1962 through 1987, four children were diagnosed at our institution with primary germ cell malignancies of the extracranial head and neck regions. Ages of the children ranged from 2 to 44 months. Histologic findings included 2 yolk sac carcinoma (endodermal sinus tumor), 1 malignant teratoma with neuroblastoma (primitive neuroectodermal) components. Complete clinical and surgical staging was performed to rule out additional sites of disease. All patients initially underwent either biopsy or, when technically feasible, resection. Three patients received combination chemotherapy and two received irradiation. Three patients died of progressive disease. One patient who had yolk sac carcinoma of the temporomandibular region is alive and free of disease 40 months after therapy. Complete surgical resection is indicated for teratomatous tumors, if technically feasible. The malignant components of these tumors are sensitive to both chemotherapy and irradiation and combined therapy may be beneficial.

Original languageEnglish (US)
Pages (from-to)732-735
Number of pages4
JournalLaryngoscope
Volume99
Issue number7
StatePublished - Jan 1 1989

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Germ Cell and Embryonal Neoplasms
Neck
Head
Yolk Sac
Endodermal Sinus Tumor
Carcinoma
Neoplasms
Teratoma
Combination Drug Therapy
Neuroblastoma
Germ Cells
Biopsy
Drug Therapy
Therapeutics

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Stephenson, J. A., Mayland, D. M., Kun, L. E., Etcubanas, E., Thompson, E. I., & Gross, C. W. (1989). Malignant germ cell tumors of the head and neck in childhood. Laryngoscope, 99(7), 732-735.

Malignant germ cell tumors of the head and neck in childhood. / Stephenson, Jeffery A.; Mayland, Diane M.; Kun, Larry E.; Etcubanas, Erlinda; Thompson, Elizabeth I.; Gross, Charles W.

In: Laryngoscope, Vol. 99, No. 7, 01.01.1989, p. 732-735.

Research output: Contribution to journalArticle

Stephenson, JA, Mayland, DM, Kun, LE, Etcubanas, E, Thompson, EI & Gross, CW 1989, 'Malignant germ cell tumors of the head and neck in childhood', Laryngoscope, vol. 99, no. 7, pp. 732-735.
Stephenson JA, Mayland DM, Kun LE, Etcubanas E, Thompson EI, Gross CW. Malignant germ cell tumors of the head and neck in childhood. Laryngoscope. 1989 Jan 1;99(7):732-735.
Stephenson, Jeffery A. ; Mayland, Diane M. ; Kun, Larry E. ; Etcubanas, Erlinda ; Thompson, Elizabeth I. ; Gross, Charles W. / Malignant germ cell tumors of the head and neck in childhood. In: Laryngoscope. 1989 ; Vol. 99, No. 7. pp. 732-735.
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