Mammographic density changes in surgical weight loss-an indication for personalized screening

Natalia Partain, Ali Mokdad, Nancy Puzziferri, Jessica Porembka, Stephen Seiler, Alana Christie, Deborah Farr, Aeisha Rivers, A. Marilyn Leitch, Rachel Wooldridge, James Huth, Roshni Rao

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Obesity and high radiologic breast density independently increase breast cancer risk. We evaluated the effect of surgical weight loss on mammographic density (MD). Methods: Patients undergoing bariatric surgery and screening mammography (MG) were identified, data regarding demographics, comorbidities, calculated and genetic breast cancer risk was collected. Patients had a MG before and after surgery. Fellowship-trained breast radiologists assigned Breast Imaging Reporting and Data System density categories. Results: Patients underwent sleeve gastrectomy (n=56) or gastric bypass (n=7), 78% had hypertension, 48% had diabetes. Four had deleterious BRCA mutations, four were calculated high risk. Mean weight loss=28.7kg. Mean initial BMI=44.3kg/m2 (range:33-77), final BMI=33.6kg/m2 (range:20-62;p<0.01). Density was unchanged in 53, decreased in 1, increased in 9. Of these 9(14%), 5 changed from almost entirely fatty to scattered MD, and 4 changed from scattered MD to heterogeneously dense. Mean weight loss of the 9 with increased MD was greater than the cohort (37.7vs.28.7kg;p<0.01). Conclusions: Surgical weight loss increased MD in 14%. Increased MD masks malignancies, patients may benefit from additional screening based on calculated risk assessments that include MD.

Original languageEnglish (US)
Article number10
JournalBMC Medical Imaging
Volume18
Issue number1
DOIs
StatePublished - May 9 2018

Fingerprint

Weight Loss
Mammography
Breast
Breast Neoplasms
Bariatric Surgery
Gastric Bypass
Breast Density
Gastrectomy
Masks
Information Systems
Comorbidity
Obesity
Demography
Hypertension
Mutation
Neoplasms

Keywords

  • Bariatric surgery
  • Breast cancer
  • Mammographic density
  • Surgical weight loss

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Mammographic density changes in surgical weight loss-an indication for personalized screening. / Partain, Natalia; Mokdad, Ali; Puzziferri, Nancy; Porembka, Jessica; Seiler, Stephen; Christie, Alana; Farr, Deborah; Rivers, Aeisha; Marilyn Leitch, A.; Wooldridge, Rachel; Huth, James; Rao, Roshni.

In: BMC Medical Imaging, Vol. 18, No. 1, 10, 09.05.2018.

Research output: Contribution to journalArticle

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abstract = "Background: Obesity and high radiologic breast density independently increase breast cancer risk. We evaluated the effect of surgical weight loss on mammographic density (MD). Methods: Patients undergoing bariatric surgery and screening mammography (MG) were identified, data regarding demographics, comorbidities, calculated and genetic breast cancer risk was collected. Patients had a MG before and after surgery. Fellowship-trained breast radiologists assigned Breast Imaging Reporting and Data System density categories. Results: Patients underwent sleeve gastrectomy (n=56) or gastric bypass (n=7), 78{\%} had hypertension, 48{\%} had diabetes. Four had deleterious BRCA mutations, four were calculated high risk. Mean weight loss=28.7kg. Mean initial BMI=44.3kg/m2 (range:33-77), final BMI=33.6kg/m2 (range:20-62;p<0.01). Density was unchanged in 53, decreased in 1, increased in 9. Of these 9(14{\%}), 5 changed from almost entirely fatty to scattered MD, and 4 changed from scattered MD to heterogeneously dense. Mean weight loss of the 9 with increased MD was greater than the cohort (37.7vs.28.7kg;p<0.01). Conclusions: Surgical weight loss increased MD in 14{\%}. Increased MD masks malignancies, patients may benefit from additional screening based on calculated risk assessments that include MD.",
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AU - Christie, Alana

AU - Farr, Deborah

AU - Rivers, Aeisha

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