Management of primary T1–T4 glottic squamous cell carcinoma by transoral laser microsurgery

Andrew T. Day, Parul Sinha, Brian Nussenbaum, Dorina Kallogjeri, Bruce H. Haughey

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objectives/Hypothesis: Evaluate the oncologic outcomes of patients with early and select advanced primary glottic squamous cell carcinoma (SCCa) managed by transoral laser microsurgery (TLM). Study Design: Retrospective cohort study. Methods: Ninety cases of TLM-managed primary glottic SCCa were identified retrospectively using a prospectively collected database. Results: Outcomes of patients with pTis–pT2a disease (n = 65) and pT2b–pT4a disease (n = 25) were, respectively: 5-year local control, 86.2% and 67.5%; 5-year disease-free survival, 64.9% and 44.9%; 5-year disease-specific survival, 96.4% and 59.0%; laryngeal preservation, 96.9% and 80%. Five of nine patients (56%) with supraglottic–glottic–subglottic tumors were local recurrence-free compared to the 70 of 81 (86%) patients with glottic, supraglottic–glottic, and glottic–subglottic tumors. Seven of 13 patients (54%) with positive or indeterminate margins were local recurrence-free compared to 68 of 77 (88%) patients with negative margins. Conclusions: Given sample size considerations, this study highlights the satisfactory oncologic outcomes of TLM-treated glottic cancer and the potential importance of margin management and disease extension within the larynx. Level of Evidence: 4 Laryngoscope, 127:597–604, 2017.

Original languageEnglish (US)
Pages (from-to)597-604
Number of pages8
JournalLaryngoscope
Volume127
Issue number3
DOIs
StatePublished - Mar 1 2017

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Microsurgery
Tongue
Squamous Cell Carcinoma
Lasers
Tongue Neoplasms
Laryngoscopes
Recurrence
Larynx
Disease Management
Sample Size
Disease-Free Survival
Neoplasms
Cohort Studies
Retrospective Studies
Databases
Survival

Keywords

  • early glottic cancer
  • head and neck
  • laryngology
  • Larynx

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Management of primary T1–T4 glottic squamous cell carcinoma by transoral laser microsurgery. / Day, Andrew T.; Sinha, Parul; Nussenbaum, Brian; Kallogjeri, Dorina; Haughey, Bruce H.

In: Laryngoscope, Vol. 127, No. 3, 01.03.2017, p. 597-604.

Research output: Contribution to journalArticle

Day, Andrew T. ; Sinha, Parul ; Nussenbaum, Brian ; Kallogjeri, Dorina ; Haughey, Bruce H. / Management of primary T1–T4 glottic squamous cell carcinoma by transoral laser microsurgery. In: Laryngoscope. 2017 ; Vol. 127, No. 3. pp. 597-604.
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abstract = "Objectives/Hypothesis: Evaluate the oncologic outcomes of patients with early and select advanced primary glottic squamous cell carcinoma (SCCa) managed by transoral laser microsurgery (TLM). Study Design: Retrospective cohort study. Methods: Ninety cases of TLM-managed primary glottic SCCa were identified retrospectively using a prospectively collected database. Results: Outcomes of patients with pTis–pT2a disease (n = 65) and pT2b–pT4a disease (n = 25) were, respectively: 5-year local control, 86.2{\%} and 67.5{\%}; 5-year disease-free survival, 64.9{\%} and 44.9{\%}; 5-year disease-specific survival, 96.4{\%} and 59.0{\%}; laryngeal preservation, 96.9{\%} and 80{\%}. Five of nine patients (56{\%}) with supraglottic–glottic–subglottic tumors were local recurrence-free compared to the 70 of 81 (86{\%}) patients with glottic, supraglottic–glottic, and glottic–subglottic tumors. Seven of 13 patients (54{\%}) with positive or indeterminate margins were local recurrence-free compared to 68 of 77 (88{\%}) patients with negative margins. Conclusions: Given sample size considerations, this study highlights the satisfactory oncologic outcomes of TLM-treated glottic cancer and the potential importance of margin management and disease extension within the larynx. Level of Evidence: 4 Laryngoscope, 127:597–604, 2017.",
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