Mapping of functional areas in the human cortex based on connectivity through association fibers

Kegang Hua, Kenichi Oishi, Jiangyang Zhang, Setsu Wakana, Takashi Yoshioka, Weihong Zhang, Kazi Dilruba Akhter, Xin Li, Hao Huang, Hangyi Jiang, Peter Van Zijl, Susumu Mori

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

In the human brain, different regions of the cortex communicate via white matter tracts. Investigation of this connectivity is essential for understanding brain function. It has been shown that trajectories of white matter fiber bundles can be estimated based on orientational information that is obtained from diffusion tensor imaging (DTI). By extrapolating this information, cortical regions associated with a specific white matter tract can be estimated. In this study, we created population-averaged cortical maps of brain connectivity for 4 major association fiber tracts, the corticospinal tract (CST), and commissural fibers. It is shown that these 4 association fibers interconnect all 4 lobes of the hemispheres. Cortical regions that were assigned based on association with the CST and the superior longitudinal fasciculus (SLF) agreed with locations of their known (CST: motor) or putative (SLF: language) functions. The proposed approach can potentially be used for quantitative assessment of the effect of white matter abnormalities on associated cortical regions.

Original languageEnglish (US)
Pages (from-to)1889-1895
Number of pages7
JournalCerebral Cortex
Volume19
Issue number8
DOIs
StatePublished - Aug 2009

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Pyramidal Tracts
Brain
Diffusion Tensor Imaging
Language
White Matter
Population

Keywords

  • Brodmann area
  • Cortical connectivity
  • Diffusion tensor imaging
  • Fiber tracts
  • Tractography
  • White matter atlas

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Hua, K., Oishi, K., Zhang, J., Wakana, S., Yoshioka, T., Zhang, W., ... Mori, S. (2009). Mapping of functional areas in the human cortex based on connectivity through association fibers. Cerebral Cortex, 19(8), 1889-1895. https://doi.org/10.1093/cercor/bhn215

Mapping of functional areas in the human cortex based on connectivity through association fibers. / Hua, Kegang; Oishi, Kenichi; Zhang, Jiangyang; Wakana, Setsu; Yoshioka, Takashi; Zhang, Weihong; Akhter, Kazi Dilruba; Li, Xin; Huang, Hao; Jiang, Hangyi; Van Zijl, Peter; Mori, Susumu.

In: Cerebral Cortex, Vol. 19, No. 8, 08.2009, p. 1889-1895.

Research output: Contribution to journalArticle

Hua, K, Oishi, K, Zhang, J, Wakana, S, Yoshioka, T, Zhang, W, Akhter, KD, Li, X, Huang, H, Jiang, H, Van Zijl, P & Mori, S 2009, 'Mapping of functional areas in the human cortex based on connectivity through association fibers', Cerebral Cortex, vol. 19, no. 8, pp. 1889-1895. https://doi.org/10.1093/cercor/bhn215
Hua, Kegang ; Oishi, Kenichi ; Zhang, Jiangyang ; Wakana, Setsu ; Yoshioka, Takashi ; Zhang, Weihong ; Akhter, Kazi Dilruba ; Li, Xin ; Huang, Hao ; Jiang, Hangyi ; Van Zijl, Peter ; Mori, Susumu. / Mapping of functional areas in the human cortex based on connectivity through association fibers. In: Cerebral Cortex. 2009 ; Vol. 19, No. 8. pp. 1889-1895.
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