Master regulation of bile acid and xenobiotic metabolism via the FXR, PXR and CAR trio

Salvatore Modica, Elena Bellafante, Antonio Moschetta

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Recent discoveries highlighted intriguing molecular pathways that regulate synthesis, uptake, metabolism and excretion of bile acids and xenobiotics. The knowledge of factors that control these homeostatic processes is of clinical relevance to better understand the drug-drug interacting scenario as well as to control cholesterol detoxification, cholestasis and other conditions. Here we present evidences for the existence of a gut-liver safety network whereby activation of the nuclear receptor FXR, PXR, CAR trio provides protection against accumulation of exogenous and metabolic noxae.

Original languageEnglish (US)
Pages (from-to)4719-4745
Number of pages27
JournalFrontiers in Bioscience
Volume14
Issue number12
DOIs
StatePublished - Jan 1 2009

Keywords

  • Bile
  • Cholestasis
  • Cholesterol
  • Gene expression
  • Intestine
  • Lipids
  • Liver
  • Nuclear receptors
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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