TY - JOUR
T1 - Maternal and fetal pharmacokinetics of moxalactam given intrapartum
AU - Bawdon, Roger E.
AU - Cunningham, F. Gary
AU - Quirk, J. Gerald
AU - Roark, Micki L.
PY - 1982/11/1
Y1 - 1982/11/1
N2 - Two grams of moxalactam was given intravenously to 28 women at high risk for infection following cesarean delivery. After a mean time of 48 minutes from infusion, maternal sera, cord sera, and uterine tissue obtained at delivery had concentrations of moxalactam of 62 μg/ml, 22.2 μg/ml, and 9.6 μg/gm, respectively. The maternal serum half-time was calculated to be 2.1 hours. R and S epimeric distribution was determined in these sera and tissues, and the mean R S ratios were 0.95, 0.93, and 1.22 for the three groups, respectively. The significance of these observations is discussed. A new method in which a high-pressure liquid chromatographic assay is used is described, and results are compared to those obtained with the microbiological assay. The high-pressure liquid chromatographic method was found to be quick, accurate, and reproducible.
AB - Two grams of moxalactam was given intravenously to 28 women at high risk for infection following cesarean delivery. After a mean time of 48 minutes from infusion, maternal sera, cord sera, and uterine tissue obtained at delivery had concentrations of moxalactam of 62 μg/ml, 22.2 μg/ml, and 9.6 μg/gm, respectively. The maternal serum half-time was calculated to be 2.1 hours. R and S epimeric distribution was determined in these sera and tissues, and the mean R S ratios were 0.95, 0.93, and 1.22 for the three groups, respectively. The significance of these observations is discussed. A new method in which a high-pressure liquid chromatographic assay is used is described, and results are compared to those obtained with the microbiological assay. The high-pressure liquid chromatographic method was found to be quick, accurate, and reproducible.
UR - http://www.scopus.com/inward/record.url?scp=0019906452&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019906452&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(82)90225-3
DO - 10.1016/0002-9378(82)90225-3
M3 - Article
C2 - 6215864
AN - SCOPUS:0019906452
SN - 0002-9378
VL - 144
SP - 546
EP - 550
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 5
ER -