Maternal high-fat diet is associated with impaired fetal lung development

Reina S. Mayor, Katelyn E. Finch, Jordan Zehr, Eugenia Morselli, Michael D. Neinast, Aaron P. Frank, Lisa D. Hahner, Jason Wang, Dinesh Rakheja, Biff F Palmer, Charles R Rosenfeld, Rashmin C Savani, Deborah J. Clegg

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Maternal nutrition has a profound long-term impact on infant health. Poor maternal nutrition influences placental development and fetal growth, resulting in low birth weight, which is strongly associated with the risk of developing chronic diseases, including heart disease, hypertension, asthma, and type 2 diabetes, later in life. Few studies have delineated the mechanisms by which maternal nutrition affects fetal lung development. Here, we report that maternal exposure to a diet high in fat (HFD) causes placental inflammation, resulting in placental insufficiency, fetal growth restriction (FGR), and inhibition of fetal lung development. Notably, pre- and postnatal exposure to maternal HFD also results in persistent alveolar simplification in the postnatal period. Our novel findings provide a strong association between maternal diet and fetal lung development.

Original languageEnglish (US)
Pages (from-to)L360-L368
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume309
Issue number4
DOIs
StatePublished - Aug 18 2015

Fingerprint

High Fat Diet
Fetal Development
Mothers
Lung
Maternal Exposure
Placental Insufficiency
Placentation
Low Birth Weight Infant
Type 2 Diabetes Mellitus
Heart Diseases
Chronic Disease
Asthma
Diet
Hypertension
Inflammation

Keywords

  • Chorioamnionitis
  • Fetal growth restriction
  • Intrauterine growth restriction
  • Placental inflammation
  • Respiratory distress syndrome

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology (medical)
  • Cell Biology
  • Physiology

Cite this

Mayor, R. S., Finch, K. E., Zehr, J., Morselli, E., Neinast, M. D., Frank, A. P., ... Clegg, D. J. (2015). Maternal high-fat diet is associated with impaired fetal lung development. American Journal of Physiology - Lung Cellular and Molecular Physiology, 309(4), L360-L368. https://doi.org/10.1152/ajplung.00105.2015

Maternal high-fat diet is associated with impaired fetal lung development. / Mayor, Reina S.; Finch, Katelyn E.; Zehr, Jordan; Morselli, Eugenia; Neinast, Michael D.; Frank, Aaron P.; Hahner, Lisa D.; Wang, Jason; Rakheja, Dinesh; Palmer, Biff F; Rosenfeld, Charles R; Savani, Rashmin C; Clegg, Deborah J.

In: American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 309, No. 4, 18.08.2015, p. L360-L368.

Research output: Contribution to journalArticle

Mayor, Reina S. ; Finch, Katelyn E. ; Zehr, Jordan ; Morselli, Eugenia ; Neinast, Michael D. ; Frank, Aaron P. ; Hahner, Lisa D. ; Wang, Jason ; Rakheja, Dinesh ; Palmer, Biff F ; Rosenfeld, Charles R ; Savani, Rashmin C ; Clegg, Deborah J. / Maternal high-fat diet is associated with impaired fetal lung development. In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 2015 ; Vol. 309, No. 4. pp. L360-L368.
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