Maternal occupational exposure to polycyclic aromatic hydrocarbons and craniosynostosis among offspring in the national birth defects prevention study

National Birth Defects Prevention Study

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Evidence in animal models and humans suggests that exposure to polycyclic aromatic hydrocarbons (PAHs) may lead to birth defects. To our knowledge, this relationship has not been evaluated for craniosynostosis, a birth defect characterized by the premature closure of sutures in the skull. We conducted a case-control study to examine associations between maternal occupational exposure to PAHs and craniosynostosis. Methods: We used data from craniosynostosis cases and control infants in the National Birth Defects Prevention Study (NBDPS) with estimated delivery dates from 1997 to 2002. Industrial hygienists reviewed occupational data from the computer-assisted telephone interview and assigned a yes/no rating of probable occupational PAH exposure for each job from 1 month before conception through delivery. We used logistic regression to assess the association between occupational exposure to PAHs and craniosynostosis. Results: The prevalence of exposure was 5.3% in case mothers (16/300) and 3.7% in control mothers (107/2,886). We observed a positive association between exposure to PAHs during the 1 month before conception through the third month of pregnancy and craniosynostosis (odds ratio [OR]=1.75; 95% confidence interval [CI], 1.01-3.05) after adjusting for maternal age and maternal education. The number of cases for each craniosynostosis subtype limited subtype analyses to sagittal craniosynostosis; the odds ratio remained similar (OR=1.76, 95% CI, 0.82-3.75), but was not significant. Conclusion: Our findings support a moderate association between maternal occupational exposure to PAHs and craniosynostosis. Additional work is needed to better characterize susceptibility and the role PAHs may play on specific craniosynostosis subtypes. Birth Defects Research (Part A) 106:55-60, 2016.

Original languageEnglish (US)
Pages (from-to)55-60
Number of pages6
JournalBirth Defects Research Part A - Clinical and Molecular Teratology
Volume106
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Maternal Exposure
Craniosynostoses
Polycyclic Aromatic Hydrocarbons
Occupational Exposure
Odds Ratio
Mothers
Confidence Intervals
Maternal Age
Skull
Sutures
Case-Control Studies
Animal Models
Logistic Models
Interviews
Education
Pregnancy

Keywords

  • Birth defects
  • Case-control
  • Craniosynostosis
  • Polycyclic aromatic hydrocarbon (PAH)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Developmental Biology

Cite this

@article{5d90c9c2751d47a792051948cf105aa6,
title = "Maternal occupational exposure to polycyclic aromatic hydrocarbons and craniosynostosis among offspring in the national birth defects prevention study",
abstract = "Background: Evidence in animal models and humans suggests that exposure to polycyclic aromatic hydrocarbons (PAHs) may lead to birth defects. To our knowledge, this relationship has not been evaluated for craniosynostosis, a birth defect characterized by the premature closure of sutures in the skull. We conducted a case-control study to examine associations between maternal occupational exposure to PAHs and craniosynostosis. Methods: We used data from craniosynostosis cases and control infants in the National Birth Defects Prevention Study (NBDPS) with estimated delivery dates from 1997 to 2002. Industrial hygienists reviewed occupational data from the computer-assisted telephone interview and assigned a yes/no rating of probable occupational PAH exposure for each job from 1 month before conception through delivery. We used logistic regression to assess the association between occupational exposure to PAHs and craniosynostosis. Results: The prevalence of exposure was 5.3{\%} in case mothers (16/300) and 3.7{\%} in control mothers (107/2,886). We observed a positive association between exposure to PAHs during the 1 month before conception through the third month of pregnancy and craniosynostosis (odds ratio [OR]=1.75; 95{\%} confidence interval [CI], 1.01-3.05) after adjusting for maternal age and maternal education. The number of cases for each craniosynostosis subtype limited subtype analyses to sagittal craniosynostosis; the odds ratio remained similar (OR=1.76, 95{\%} CI, 0.82-3.75), but was not significant. Conclusion: Our findings support a moderate association between maternal occupational exposure to PAHs and craniosynostosis. Additional work is needed to better characterize susceptibility and the role PAHs may play on specific craniosynostosis subtypes. Birth Defects Research (Part A) 106:55-60, 2016.",
keywords = "Birth defects, Case-control, Craniosynostosis, Polycyclic aromatic hydrocarbon (PAH)",
author = "{National Birth Defects Prevention Study} and O'Brien, {Jacqueline L.} and Langlois, {Peter H.} and Lawson, {Christina C.} and Angela Scheuerle and Rocheleau, {Carissa M.} and Waters, {Martha A.} and Elaine Symanski and Romitti, {Paul A.} and Agopian, {A. J.} and Lupo, {Philip J.}",
year = "2016",
month = "1",
day = "1",
doi = "10.1002/bdra.23389",
language = "English (US)",
volume = "106",
pages = "55--60",
journal = "Teratology",
issn = "1542-0752",
publisher = "Wiley-Liss Inc.",
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T1 - Maternal occupational exposure to polycyclic aromatic hydrocarbons and craniosynostosis among offspring in the national birth defects prevention study

AU - National Birth Defects Prevention Study

AU - O'Brien, Jacqueline L.

AU - Langlois, Peter H.

AU - Lawson, Christina C.

AU - Scheuerle, Angela

AU - Rocheleau, Carissa M.

AU - Waters, Martha A.

AU - Symanski, Elaine

AU - Romitti, Paul A.

AU - Agopian, A. J.

AU - Lupo, Philip J.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: Evidence in animal models and humans suggests that exposure to polycyclic aromatic hydrocarbons (PAHs) may lead to birth defects. To our knowledge, this relationship has not been evaluated for craniosynostosis, a birth defect characterized by the premature closure of sutures in the skull. We conducted a case-control study to examine associations between maternal occupational exposure to PAHs and craniosynostosis. Methods: We used data from craniosynostosis cases and control infants in the National Birth Defects Prevention Study (NBDPS) with estimated delivery dates from 1997 to 2002. Industrial hygienists reviewed occupational data from the computer-assisted telephone interview and assigned a yes/no rating of probable occupational PAH exposure for each job from 1 month before conception through delivery. We used logistic regression to assess the association between occupational exposure to PAHs and craniosynostosis. Results: The prevalence of exposure was 5.3% in case mothers (16/300) and 3.7% in control mothers (107/2,886). We observed a positive association between exposure to PAHs during the 1 month before conception through the third month of pregnancy and craniosynostosis (odds ratio [OR]=1.75; 95% confidence interval [CI], 1.01-3.05) after adjusting for maternal age and maternal education. The number of cases for each craniosynostosis subtype limited subtype analyses to sagittal craniosynostosis; the odds ratio remained similar (OR=1.76, 95% CI, 0.82-3.75), but was not significant. Conclusion: Our findings support a moderate association between maternal occupational exposure to PAHs and craniosynostosis. Additional work is needed to better characterize susceptibility and the role PAHs may play on specific craniosynostosis subtypes. Birth Defects Research (Part A) 106:55-60, 2016.

AB - Background: Evidence in animal models and humans suggests that exposure to polycyclic aromatic hydrocarbons (PAHs) may lead to birth defects. To our knowledge, this relationship has not been evaluated for craniosynostosis, a birth defect characterized by the premature closure of sutures in the skull. We conducted a case-control study to examine associations between maternal occupational exposure to PAHs and craniosynostosis. Methods: We used data from craniosynostosis cases and control infants in the National Birth Defects Prevention Study (NBDPS) with estimated delivery dates from 1997 to 2002. Industrial hygienists reviewed occupational data from the computer-assisted telephone interview and assigned a yes/no rating of probable occupational PAH exposure for each job from 1 month before conception through delivery. We used logistic regression to assess the association between occupational exposure to PAHs and craniosynostosis. Results: The prevalence of exposure was 5.3% in case mothers (16/300) and 3.7% in control mothers (107/2,886). We observed a positive association between exposure to PAHs during the 1 month before conception through the third month of pregnancy and craniosynostosis (odds ratio [OR]=1.75; 95% confidence interval [CI], 1.01-3.05) after adjusting for maternal age and maternal education. The number of cases for each craniosynostosis subtype limited subtype analyses to sagittal craniosynostosis; the odds ratio remained similar (OR=1.76, 95% CI, 0.82-3.75), but was not significant. Conclusion: Our findings support a moderate association between maternal occupational exposure to PAHs and craniosynostosis. Additional work is needed to better characterize susceptibility and the role PAHs may play on specific craniosynostosis subtypes. Birth Defects Research (Part A) 106:55-60, 2016.

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KW - Case-control

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KW - Polycyclic aromatic hydrocarbon (PAH)

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