Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity

Yang Du, Marie Yang, Syann Lee, Cassie L. Behrendt, Lora V. Hooper, Alan Saghatelian, Yihong Wan

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

For all newborn mammals, mother's milk is the perfect nourishment, crucial for their postnatal development. Here we report that, unexpectedly, maternal western diet consumption in mice causes the production of toxic milk that contains excessive long chain and saturated fatty acids, which triggers ceramide accumulation and inflammation in the nursing neonates, manifested as alopecia. This neonatal toxicity requires Toll-like-receptors (TLR), but not gut microbiota, because TLR2/4 deletion or TLR4 inhibition confers resistance, whereas germ-free mice remain sensitive. These findings unravel maternal western diet-induced inflammatory milk secretion as a novel aspect of the metabolic syndrome at the maternal offspring interface.

Original languageEnglish (US)
Pages (from-to)1306-1311
Number of pages6
JournalGenes and Development
Volume26
Issue number12
DOIs
StatePublished - Jun 2012

Fingerprint

Milk
Mothers
Ceramides
Poisons
Toll-Like Receptors
Alopecia
Mammals
Nursing
Fatty Acids
Inflammation
Western Diet
Gastrointestinal Microbiome

Keywords

  • Metabolism
  • Milk
  • Neonatal inflammation

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity. / Du, Yang; Yang, Marie; Lee, Syann; Behrendt, Cassie L.; Hooper, Lora V.; Saghatelian, Alan; Wan, Yihong.

In: Genes and Development, Vol. 26, No. 12, 06.2012, p. 1306-1311.

Research output: Contribution to journalArticle

Du, Yang ; Yang, Marie ; Lee, Syann ; Behrendt, Cassie L. ; Hooper, Lora V. ; Saghatelian, Alan ; Wan, Yihong. / Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity. In: Genes and Development. 2012 ; Vol. 26, No. 12. pp. 1306-1311.
@article{a5e496a9298a4f32be3d3d866620e8b5,
title = "Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity",
abstract = "For all newborn mammals, mother's milk is the perfect nourishment, crucial for their postnatal development. Here we report that, unexpectedly, maternal western diet consumption in mice causes the production of toxic milk that contains excessive long chain and saturated fatty acids, which triggers ceramide accumulation and inflammation in the nursing neonates, manifested as alopecia. This neonatal toxicity requires Toll-like-receptors (TLR), but not gut microbiota, because TLR2/4 deletion or TLR4 inhibition confers resistance, whereas germ-free mice remain sensitive. These findings unravel maternal western diet-induced inflammatory milk secretion as a novel aspect of the metabolic syndrome at the maternal offspring interface.",
keywords = "Metabolism, Milk, Neonatal inflammation",
author = "Yang Du and Marie Yang and Syann Lee and Behrendt, {Cassie L.} and Hooper, {Lora V.} and Alan Saghatelian and Yihong Wan",
year = "2012",
month = "6",
doi = "10.1101/gad.191031.112",
language = "English (US)",
volume = "26",
pages = "1306--1311",
journal = "Genes and Development",
issn = "0890-9369",
publisher = "Cold Spring Harbor Laboratory Press",
number = "12",

}

TY - JOUR

T1 - Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity

AU - Du, Yang

AU - Yang, Marie

AU - Lee, Syann

AU - Behrendt, Cassie L.

AU - Hooper, Lora V.

AU - Saghatelian, Alan

AU - Wan, Yihong

PY - 2012/6

Y1 - 2012/6

N2 - For all newborn mammals, mother's milk is the perfect nourishment, crucial for their postnatal development. Here we report that, unexpectedly, maternal western diet consumption in mice causes the production of toxic milk that contains excessive long chain and saturated fatty acids, which triggers ceramide accumulation and inflammation in the nursing neonates, manifested as alopecia. This neonatal toxicity requires Toll-like-receptors (TLR), but not gut microbiota, because TLR2/4 deletion or TLR4 inhibition confers resistance, whereas germ-free mice remain sensitive. These findings unravel maternal western diet-induced inflammatory milk secretion as a novel aspect of the metabolic syndrome at the maternal offspring interface.

AB - For all newborn mammals, mother's milk is the perfect nourishment, crucial for their postnatal development. Here we report that, unexpectedly, maternal western diet consumption in mice causes the production of toxic milk that contains excessive long chain and saturated fatty acids, which triggers ceramide accumulation and inflammation in the nursing neonates, manifested as alopecia. This neonatal toxicity requires Toll-like-receptors (TLR), but not gut microbiota, because TLR2/4 deletion or TLR4 inhibition confers resistance, whereas germ-free mice remain sensitive. These findings unravel maternal western diet-induced inflammatory milk secretion as a novel aspect of the metabolic syndrome at the maternal offspring interface.

KW - Metabolism

KW - Milk

KW - Neonatal inflammation

UR - http://www.scopus.com/inward/record.url?scp=84862615760&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862615760&partnerID=8YFLogxK

U2 - 10.1101/gad.191031.112

DO - 10.1101/gad.191031.112

M3 - Article

VL - 26

SP - 1306

EP - 1311

JO - Genes and Development

JF - Genes and Development

SN - 0890-9369

IS - 12

ER -