Mechanically Tunable Hollow Silica Ultrathin Nanoshells for Ultrasound Contrast Agents

A. Liberman, James Wang, N. Lu, Robert D. Viveros, C. A. Allen, R. F. Mattrey, S. L. Blair, W. C. Trogler, M. J. Kim, A. C. Kummel

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Perfluoropentane (PFP) gas-filled biodegradable iron-doped silica nanoshells have been demonstrated as long-lived ultrasound contrast agents. Nanoshells are synthesized by a sol-gel process with tetramethyl orthosilicate (TMOS) and iron ethoxide. Substituting a fraction of the TMOS with R-substituted-trialkoxysilanes produces ultrathin nanoshells with varying shell thicknesses and morphologies composed of fused nanoflakes. The ultrathin nanoshells have continuous ultrasound Doppler imaging lifetimes exceeding 3 h, are twice as bright using contrast-specific imaging, and have decreased pressure thresholds compared to control nanoshells synthesized with just TMOS. Transmission electron microscopy shows that the R-group-substituted trialkoxysilanes can reduce the mechanically critical nanoshell layer to 1.4 nm. These ultrathin nanoshells have the mechanical behavior of weakly linked nanoflakes but the chemical stability of silica. The synthesis can be adapted for general fabrication of 3D nanostructures composed of nanoflakes, which have thicknesses from 1.4 to 3.8 nm and diameters from 2 to 23 nm. Ultrathin hollow silica nanoshells can be synthesized by substituting in organically modified trialkoxysilanes into existing nanoshell syntheses. The resulting nanoshells have much thinner shell walls, which result in dramatic improvement in applications as ultrasound contrast agents.

Original languageEnglish (US)
Pages (from-to)4049-4057
Number of pages9
JournalAdvanced Functional Materials
Volume25
Issue number26
DOIs
StatePublished - Jul 1 2015

Fingerprint

Nanoshells
Silicon Dioxide
Contrast Media
hollow
Ultrasonics
Silica
silicon dioxide
iron
sol-gel processes
synthesis
life (durability)
transmission electron microscopy
fabrication
thresholds
gases
Iron
Imaging techniques
Chemical stability
Sol-gel process
Nanostructures

Keywords

  • biomedical imaging
  • core/shell nanoparticles
  • nanoflakes
  • silica
  • sol-gel

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Condensed Matter Physics
  • Electrochemistry

Cite this

Mechanically Tunable Hollow Silica Ultrathin Nanoshells for Ultrasound Contrast Agents. / Liberman, A.; Wang, James; Lu, N.; Viveros, Robert D.; Allen, C. A.; Mattrey, R. F.; Blair, S. L.; Trogler, W. C.; Kim, M. J.; Kummel, A. C.

In: Advanced Functional Materials, Vol. 25, No. 26, 01.07.2015, p. 4049-4057.

Research output: Contribution to journalArticle

Liberman, A, Wang, J, Lu, N, Viveros, RD, Allen, CA, Mattrey, RF, Blair, SL, Trogler, WC, Kim, MJ & Kummel, AC 2015, 'Mechanically Tunable Hollow Silica Ultrathin Nanoshells for Ultrasound Contrast Agents', Advanced Functional Materials, vol. 25, no. 26, pp. 4049-4057. https://doi.org/10.1002/adfm.201500610
Liberman, A. ; Wang, James ; Lu, N. ; Viveros, Robert D. ; Allen, C. A. ; Mattrey, R. F. ; Blair, S. L. ; Trogler, W. C. ; Kim, M. J. ; Kummel, A. C. / Mechanically Tunable Hollow Silica Ultrathin Nanoshells for Ultrasound Contrast Agents. In: Advanced Functional Materials. 2015 ; Vol. 25, No. 26. pp. 4049-4057.
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