Mechanism of hypokalemia in magnesium deficiency

Chou Long Huang, Elizabeth Kuo

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Magnesium deficiency is frequently associated with hypokalemia. Concomitant magnesium deficiency aggravates hypokalemia and renders it refractory to treatment by potassium. Herein is reviewed literature suggesting that magnesium deficiency exacerbates potassium wasting by increasing distal potassium secretion. A decrease in intracellular magnesium, caused by magnesium deficiency, releases the magnesium-mediated inhibition of ROMK channels and increases potassium secretion. Magnesium deficiency alone, however, does not necessarily cause hypokalemia. An increase in distal sodium delivery or elevated aldosterone levels may be required for exacerbating potassium wasting in magnesium deficiency.

Original languageEnglish (US)
Pages (from-to)2649-2652
Number of pages4
JournalJournal of the American Society of Nephrology
Volume18
Issue number10
DOIs
StatePublished - Oct 2007

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Magnesium Deficiency
Hypokalemia
Potassium
Magnesium
Potassium Channels
Aldosterone
Sodium

ASJC Scopus subject areas

  • Nephrology

Cite this

Mechanism of hypokalemia in magnesium deficiency. / Huang, Chou Long; Kuo, Elizabeth.

In: Journal of the American Society of Nephrology, Vol. 18, No. 10, 10.2007, p. 2649-2652.

Research output: Contribution to journalArticle

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