Mechanism of hypokalemia in magnesium deficiency

Chou Long Huang, Elizabeth Kuo

Research output: Contribution to journalReview article

150 Scopus citations

Abstract

Magnesium deficiency is frequently associated with hypokalemia. Concomitant magnesium deficiency aggravates hypokalemia and renders it refractory to treatment by potassium. Herein is reviewed literature suggesting that magnesium deficiency exacerbates potassium wasting by increasing distal potassium secretion. A decrease in intracellular magnesium, caused by magnesium deficiency, releases the magnesium-mediated inhibition of ROMK channels and increases potassium secretion. Magnesium deficiency alone, however, does not necessarily cause hypokalemia. An increase in distal sodium delivery or elevated aldosterone levels may be required for exacerbating potassium wasting in magnesium deficiency.

Original languageEnglish (US)
Pages (from-to)2649-2652
Number of pages4
JournalJournal of the American Society of Nephrology
Volume18
Issue number10
DOIs
StatePublished - Oct 1 2007

ASJC Scopus subject areas

  • Nephrology

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