Mechanisms of myoblast fusion during muscle development

Ji Hoon Kim, Peng Jin, Rui Duan, Elizabeth Chen

Research output: Contribution to journalReview article

104 Scopus citations

Abstract

The development and regeneration of skeletal muscle require the fusion of mononucleated muscle cells to form multinucleated, contractile muscle fibers. Studies using a simple genetic model, Drosophila melanogaster, have discovered many evolutionarily conserved fusion-promoting factors in vivo. Recent work in zebrafish and mouse also identified several vertebrate-specific factors required for myoblast fusion. Here, we integrate progress in multiple in vivo systems and highlight conceptual advance in understanding how muscle cell membranes are brought together for fusion. We focus on the molecular machinery at the fusogenic synapse and present a three-step model to describe the molecular and cellular events leading to fusion pore formation.

Original languageEnglish (US)
Pages (from-to)162-170
Number of pages9
JournalCurrent Opinion in Genetics and Development
Volume32
DOIs
StatePublished - Jun 1 2015

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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