Mechanisms that regulate stem cell aging and life span

Robert A J Signer, Sean J. Morrison

Research output: Contribution to journalReview article

191 Scopus citations


Mammalian aging is associated with reduced tissue regeneration, increased degenerative disease, and cancer. Because stem cells regenerate many adult tissues and contribute to the development of cancer by accumulating mutations, age-related changes in stem cells likely contribute to age-related morbidity. Consistent with this, stem cell function declines with age in numerous tissues as a result of gate-keeping tumor suppressor expression, DNA damage, changes in cellular physiology, and environmental changes in tissues. It remains unknown whether declines in stem cell function during aging influence organismal longevity. However, mechanisms that influence longevity also modulate age-related morbidity, partly through effects on stem cells.

Original languageEnglish (US)
Pages (from-to)152-165
Number of pages14
JournalCell Stem Cell
Issue number2
StatePublished - Feb 7 2013


ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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