Mechanisms that regulate stem cell aging and life span

Robert A J Signer; Sean J. Morrison

doi:10.1016/j.stem.2013.01.001

Mechanisms that regulate stem cell aging and life span

Robert A J Signer, Sean J. Morrison

Research output: Contribution to journal › Review article › peer-review

259 Scopus citations

Abstract

Mammalian aging is associated with reduced tissue regeneration, increased degenerative disease, and cancer. Because stem cells regenerate many adult tissues and contribute to the development of cancer by accumulating mutations, age-related changes in stem cells likely contribute to age-related morbidity. Consistent with this, stem cell function declines with age in numerous tissues as a result of gate-keeping tumor suppressor expression, DNA damage, changes in cellular physiology, and environmental changes in tissues. It remains unknown whether declines in stem cell function during aging influence organismal longevity. However, mechanisms that influence longevity also modulate age-related morbidity, partly through effects on stem cells.

Original language	English (US)
Pages (from-to)	152-165
Number of pages	14
Journal	Cell Stem Cell
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/j.stem.2013.01.001
State	Published - Feb 7 2013

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

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10.1016/j.stem.2013.01.001

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title = "Mechanisms that regulate stem cell aging and life span",

abstract = "Mammalian aging is associated with reduced tissue regeneration, increased degenerative disease, and cancer. Because stem cells regenerate many adult tissues and contribute to the development of cancer by accumulating mutations, age-related changes in stem cells likely contribute to age-related morbidity. Consistent with this, stem cell function declines with age in numerous tissues as a result of gate-keeping tumor suppressor expression, DNA damage, changes in cellular physiology, and environmental changes in tissues. It remains unknown whether declines in stem cell function during aging influence organismal longevity. However, mechanisms that influence longevity also modulate age-related morbidity, partly through effects on stem cells.",

author = "Signer, {Robert A J} and Morrison, {Sean J.}",

note = "Funding Information: This work was supported by the Howard Hughes Medical Institute, the Cancer Prevention and Research Institute of Texas, and the National Institute on Aging (R37 AG024945). R.A.J.S. is supported by fellowships from the Leukemia & Lymphoma Society (5541-11) and the Canadian Institutes of Health Research (MFE-106993). We apologize to authors whose papers we could not cite due to space limitations.",

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AU - Morrison, Sean J.

N1 - Funding Information: This work was supported by the Howard Hughes Medical Institute, the Cancer Prevention and Research Institute of Texas, and the National Institute on Aging (R37 AG024945). R.A.J.S. is supported by fellowships from the Leukemia & Lymphoma Society (5541-11) and the Canadian Institutes of Health Research (MFE-106993). We apologize to authors whose papers we could not cite due to space limitations.

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N2 - Mammalian aging is associated with reduced tissue regeneration, increased degenerative disease, and cancer. Because stem cells regenerate many adult tissues and contribute to the development of cancer by accumulating mutations, age-related changes in stem cells likely contribute to age-related morbidity. Consistent with this, stem cell function declines with age in numerous tissues as a result of gate-keeping tumor suppressor expression, DNA damage, changes in cellular physiology, and environmental changes in tissues. It remains unknown whether declines in stem cell function during aging influence organismal longevity. However, mechanisms that influence longevity also modulate age-related morbidity, partly through effects on stem cells.

AB - Mammalian aging is associated with reduced tissue regeneration, increased degenerative disease, and cancer. Because stem cells regenerate many adult tissues and contribute to the development of cancer by accumulating mutations, age-related changes in stem cells likely contribute to age-related morbidity. Consistent with this, stem cell function declines with age in numerous tissues as a result of gate-keeping tumor suppressor expression, DNA damage, changes in cellular physiology, and environmental changes in tissues. It remains unknown whether declines in stem cell function during aging influence organismal longevity. However, mechanisms that influence longevity also modulate age-related morbidity, partly through effects on stem cells.

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Mechanisms that regulate stem cell aging and life span

Abstract

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