@article{43b589bc076641549c6b1080a634b3b3,
title = "Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia",
abstract = "Whether melanocortin 4 receptors (MC4Rs) in extra-hypothalamic neurons, including cholinergic autonomic pre-ganglionic neurons, are required to control energy and glucose homeostasis is unclear. We found that MC4Rs in sympathetic, but not parasympathetic, pre-ganglionic neurons were required to regulate energy expenditure and body weight, including thermogenic responses to diet and cold exposure and 'beiging' of white adipose tissue. Deletion of Mc4r genes in both sympathetic and parasympathetic cholinergic neurons impaired glucose homeostasis.",
author = "Berglund, {Eric D.} and Tiemin Liu and Xingxing Kong and Sohn, {Jong Woo} and Linh Vong and Zhuo Deng and Lee, {Charlotte E.} and Syann Lee and Williams, {Kevin W.} and Olson, {David P.} and Scherer, {Philipp E.} and Lowell, {Bradford B.} and Elmquist, {Joel K.}",
note = "Funding Information: We thank E. Rosen (Beth Israel Deaconess Medical Center and Harvard Medical School) for assistance; personnel in the University of Texas Southwestern Mouse Phenotyping and Histology Cores; and the US National Institutes of Health Vanderbilt University Mouse Metabolic Phenotyping Core Hormone Assay and Analytical Core, supported by DK 059637. This work was supported by grants from the US National Institutes of Health (F32 DK092083 and K01 DK098317 to E.D.B., R01 DK55758 and R01 DK099110 to P.E.S., R01 DK088761 to P.E.S. and J.K.E., K01 DK087780 to K.W.W., R01 DK089044, R01 DK071051, R01 DK075632 and R37 DK053477 to B.B.L., and R01 DK088423 and R37 DK053301 to J.K.E.), a mentor-based postdoctoral fellowship from the American Diabetes Association (7-11-MN-16 to T.L.), a post-doctoral fellowship from American Heart Association (13POST16710016to X.K.), a postdoctoral fellowship from the American Heart Association (12POST8860007 to J.-W.S.), and BNORC and BADERC Transgenic Core grants P30DK046200 and P30DK057521 to B.B.L.",
year = "2014",
month = jul,
doi = "10.1038/nn.3737",
language = "English (US)",
volume = "17",
pages = "911--913",
journal = "Nature neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "7",
}