Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia

Eric D. Berglund, Tiemin Liu, Xingxing Kong, Jong Woo Sohn, Linh Vong, Zhuo Deng, Charlotte E. Lee, Syann Lee, Kevin W. Williams, David P. Olson, Philipp E. Scherer, Bradford B. Lowell, Joel K. Elmquist

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

Whether melanocortin 4 receptors (MC4Rs) in extra-hypothalamic neurons, including cholinergic autonomic pre-ganglionic neurons, are required to control energy and glucose homeostasis is unclear. We found that MC4Rs in sympathetic, but not parasympathetic, pre-ganglionic neurons were required to regulate energy expenditure and body weight, including thermogenic responses to diet and cold exposure and 'beiging' of white adipose tissue. Deletion of Mc4r genes in both sympathetic and parasympathetic cholinergic neurons impaired glucose homeostasis.

Original languageEnglish (US)
Pages (from-to)911-913
Number of pages3
JournalNature neuroscience
Volume17
Issue number7
DOIs
StatePublished - Jul 2014

ASJC Scopus subject areas

  • Neuroscience(all)

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