Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia

Eric D. Berglund, Tiemin Liu, Xingxing Kong, Jong Woo Sohn, Linh Vong, Zhuo Deng, Charlotte E. Lee, Syann Lee, Kevin W. Williams, David P. Olson, Philipp E. Scherer, Bradford B. Lowell, Joel K. Elmquist

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Whether melanocortin 4 receptors (MC4Rs) in extra-hypothalamic neurons, including cholinergic autonomic pre-ganglionic neurons, are required to control energy and glucose homeostasis is unclear. We found that MC4Rs in sympathetic, but not parasympathetic, pre-ganglionic neurons were required to regulate energy expenditure and body weight, including thermogenic responses to diet and cold exposure and 'beiging' of white adipose tissue. Deletion of Mc4r genes in both sympathetic and parasympathetic cholinergic neurons impaired glucose homeostasis.

Original languageEnglish (US)
Pages (from-to)911-913
Number of pages3
JournalNature Neuroscience
Volume17
Issue number7
DOIs
StatePublished - 2014

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Receptor, Melanocortin, Type 4
Cholinergic Neurons
Thermogenesis
Homeostasis
Neurons
Glucose
White Adipose Tissue
Gene Deletion
Energy Metabolism
Body Weight
Diet

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia. / Berglund, Eric D.; Liu, Tiemin; Kong, Xingxing; Sohn, Jong Woo; Vong, Linh; Deng, Zhuo; Lee, Charlotte E.; Lee, Syann; Williams, Kevin W.; Olson, David P.; Scherer, Philipp E.; Lowell, Bradford B.; Elmquist, Joel K.

In: Nature Neuroscience, Vol. 17, No. 7, 2014, p. 911-913.

Research output: Contribution to journalArticle

Berglund, Eric D. ; Liu, Tiemin ; Kong, Xingxing ; Sohn, Jong Woo ; Vong, Linh ; Deng, Zhuo ; Lee, Charlotte E. ; Lee, Syann ; Williams, Kevin W. ; Olson, David P. ; Scherer, Philipp E. ; Lowell, Bradford B. ; Elmquist, Joel K. / Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia. In: Nature Neuroscience. 2014 ; Vol. 17, No. 7. pp. 911-913.
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