Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing

Physics & Astronomy

• editing 90%
• genes 72%
• organs 64%
• lipids 60%
• delivery 59%
• membranes 45%
• zwitterions 19%
• ribonucleic acids 19%
• spleen 17%
• inspiration 17%
• cargo 16%
• nucleic acids 16%
• liver 13%
• lungs 13%
• escape 12%
• selectivity 11%
• cones 10%
• synthesis 8%
• nanoparticles 8%

Engineering & Materials Science

• Phospholipids 100%
• Messenger RNA 87%
• Lipids 69%
• Genes 59%
• Membranes 52%
• Biological membranes 18%
• Nucleic acids 15%
• RNA 12%
• Liver 12%
• Nanoparticles 10%
• Cones 9%
• Tissue 8%

Chemical Compounds

• Phospholipid 51%
• Lipid 35%
• Messenger RNA 13%
• Zwitterion 11%
• Multicomponent Reaction 8%
• Nucleic Acid 8%
• Hexagonal Space Group 8%
• Shape 6%
• Chemical Transformation 6%
• Environment 5%
• Nanoparticle 5%
• Application 3%