Membrane phospholipid asymmetry: Host response to the externalization of phosphatidylserine

Elizabeth M. Bruckheimer, Alan J. Schroit

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

Membrane phospholipid asymmetry is an important regulator of cellular function and homeostasis. The activities of lipid transporters are contributing factors to the regulation of membrane Lipid composition over the lifespan of the cell. Alterations in the activities of these proteins result in the movement of phosphatidylserine to the cell's outer leaflet. This promotes several physiologic responses including initiation of the coagulation cascade and cell recognition by the reticuloendothelial system.

Original languageEnglish (US)
Pages (from-to)784-788
Number of pages5
JournalJournal of Leukocyte Biology
Volume59
Issue number6
DOIs
StatePublished - Jun 1996

Keywords

  • Erythrocytes
  • Lipid asymmetry
  • Macrophages

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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