Membrane phospholipid asymmetry

Host response to the externalization of phosphatidylserine

Elizabeth M. Bruckheimer, Alan J. Schroit

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Membrane phospholipid asymmetry is an important regulator of cellular function and homeostasis. The activities of lipid transporters are contributing factors to the regulation of membrane Lipid composition over the lifespan of the cell. Alterations in the activities of these proteins result in the movement of phosphatidylserine to the cell's outer leaflet. This promotes several physiologic responses including initiation of the coagulation cascade and cell recognition by the reticuloendothelial system.

Original languageEnglish (US)
Pages (from-to)784-788
Number of pages5
JournalJournal of Leukocyte Biology
Volume59
Issue number6
StatePublished - Jun 1996

Fingerprint

Phosphatidylserines
Phospholipids
Membranes
Mononuclear Phagocyte System
Membrane Lipids
Homeostasis
Lipids
Proteins

Keywords

  • Erythrocytes
  • Lipid asymmetry
  • Macrophages

ASJC Scopus subject areas

  • Cell Biology

Cite this

Membrane phospholipid asymmetry : Host response to the externalization of phosphatidylserine. / Bruckheimer, Elizabeth M.; Schroit, Alan J.

In: Journal of Leukocyte Biology, Vol. 59, No. 6, 06.1996, p. 784-788.

Research output: Contribution to journalArticle

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